A powerful tool to study metabolic reprogramming in pediatric cancers.

Med

Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address:

Published: April 2021

Johnston et al. developed an intra-operative UC-glucose infusion protocol that is well tolerated by patients with pediatric cancers and shows cancer-type-specific metabolic alterations with therapeutical consequences. The development of this procedure and their findings will strongly benefit metabolic analysis of pediatric cancers and design of new therapeutic strategies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11191578PMC
http://dx.doi.org/10.1016/j.medj.2021.03.006DOI Listing

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