AI Article Synopsis
- Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting the central nervous system, diagnosed through clinical signs, cerebrospinal fluid tests, and MRI, though no blood-based biomarker currently exists.
- Due to the complexities of the diagnosis, there's a push for more accessible and early diagnostic methods, as well as personalized treatment strategies.
- Research is ongoing into microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) that may play significant roles in MS's neuroinflammatory processes, with some showing potential as diagnostic and prognostic biomarkers.
Article Abstract
Multiple sclerosis (MS) is a central nervous system chronic neuroinflammatory disease followed by neurodegeneration. The diagnosis is based on clinical presentation, cerebrospinal fluid testing and magnetic resonance imagining. There is still a lack of a diagnostic blood-based biomarker for MS. Due to the cost and difficulty of diagnosis, new and more easily accessible methods are being sought. New biomarkers should also allow for early diagnosis. Additionally, the treatment of MS should lead to the personalization of the therapy. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as well as their target genes participate in pathophysiology processes in MS. Although the detailed mechanism of action of non-coding RNAs (ncRNAs, including miRNAs and lncRNAs) on neuroinflammation in MS has not been fully explained, several studies were conducted aiming to analyse their impact in MS. In this article, we review up-to-date knowledge on the latest research concerning the ncRNAs in MS and evaluate their role in neuroinflammation. We also point out the most promising ncRNAs which may be promising in MS as diagnostic and prognostic biomarkers.
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| http://dx.doi.org/10.1007/s12035-022-02854-y | DOI Listing |
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