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The Impact of Linguistic Signals on Cognitive Change in Support Seekers in Online Mental Health Communities: Text Analysis and Empirical Study.
J Med Internet Res
January 2025
School of Management, Hefei University of Technology, Hefei, China.
Background: In online mental health communities, the interactions among members can significantly reduce their psychological distress and enhance their mental well-being. The overall quality of support from others varies due to differences in people's capacities to help others. This results in some support seekers' needs being met, while others remain unresolved.
View Article and Find Full Text PDFConversational repairs on Reddit: Widely initiated but often uncompleted.
PLoS One
January 2025
Department of Psychological and Behavioural Science, London School of Economics, London, United Kingdom.
Conversational repair has been proposed as a universal system for maintaining mutual understanding during social interactions. The repair system has been studied extensively in offline synchronous interactions (e.g.
View Article and Find Full Text PDFDeep learning algorithm on H&E whole slide images to characterize alterations frequency and spatial distribution in breast cancer.
Comput Struct Biotechnol J
December 2024
Division of Pathology, European Institute of Oncology IRCCS, Milan, Italy.
The tumor suppressor is frequently mutated in hormone receptor-negative, HER2-positive breast cancer (BC), contributing to tumor aggressiveness. Traditional ancillary methods like immunohistochemistry (IHC) to assess functionality face pre- and post-analytical challenges. This proof-of-concept study employed a deep learning (DL) algorithm to predict mutational status from H&E-stained whole slide images (WSIs) of BC tissue.
View Article and Find Full Text PDFSystematic analysis of lysine lactylation in nucleus pulposus cells.
iScience
November 2024
Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China.
Article Synopsis
- Nucleus pulposus cells (NPCs) live in low-oxygen conditions and primarily use glycolysis, producing high amounts of lactate, which may lead to a new type of epigenetic modification known as lysine lactylation (Kla).
- Single-cell RNA sequencing indicated that intervertebral disc degeneration (IDD) disrupts the balance between glycolysis and aerobic oxidation in NPCs.
- Extensive analysis identified over 3,500 lactylation sites on non-histone proteins, revealing a link between lactylated proteins and key cellular functions related to metabolism and signaling pathways, suggesting Kla may influence NPC cellular metabolism.
The prediction of alterations in plasma sodium levels in acutely ill patients should be more comprehensive. Author's reply.
Eur J Intern Med
January 2025
Amsterdam UMC location University of Amsterdam, Nephrology, Meibergdreef 9, Amsterdam, The Netherlands; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands. Electronic address:
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