AI Article Synopsis
- Cardiac function relies heavily on the regulation of calcium (Ca2+) levels, which is crucial across various species including invertebrates and mammals.
- The protein 4E binding protein (4E-BP) is identified as a novel regulator that enhances SERCA activity, a key player in Ca2+ handling, particularly in the hearts of Drosophila melanogaster (fruit flies).
- Flies that over-express 4E-BP exhibit better cardiac performance, and this improvement is linked to increased SERCA activity and its interaction with specific translation initiation factors, particularly eIF4E-4, in heart tissue.
Article Abstract
Appropriate cardiac performance depends on a tightly controlled handling of Ca2+ in a broad range of species, from invertebrates to mammals. The role of the Ca2+ ATPase, SERCA, in Ca2+ handling is pivotal, and its activity is regulated, inter alia, by interacting with distinct proteins. Herein, we give evidence that 4E binding protein (4E-BP) is a novel regulator of SERCA activity in Drosophila melanogaster during cardiac function. Flies over-expressing 4E-BP showed improved cardiac performance in young individuals associated with incremented SERCA activity. Moreover, we demonstrate that SERCA interacts with translation initiation factors eIF4E-1, eIF4E-2 and eIF4E-4 in a yeast two-hybrid assay. The specific identification of eIF4E-4 in cardiac tissue leads us to propose that the interaction of elF4E-4 with SERCA may be the basis of the cardiac effects observed in 4E-BP over-expressing flies associated with incremented SERCA activity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9119464 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0267156 | PLOS |
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