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Modeling and predicting single-cell multi-gene perturbation responses with scLAMBDA.
bioRxiv
December 2024
Department of Biostatistics, Yale University, CT, USA.
Understanding cellular responses to genetic perturbations is essential for understanding gene regulation and phenotype formation. While high-throughput single-cell RNA-sequencing has facilitated detailed profiling of heterogeneous transcriptional responses to perturbations at the single-cell level, there remains a pressing need for computational models that can decode the mechanisms driving these responses and accurately predict outcomes to prioritize target genes for experimental design. Here, we present scLAMBDA, a deep generative learning framework designed to model and predict single-cell transcriptional responses to genetic perturbations, including single-gene and combinatorial multi-gene perturbations.
View Article and Find Full Text PDFWithin-Person Fluctuations in Objective Smartphone Use and Emotional Processes During Adolescence: An Intensive Longitudinal Study.
Affect Sci
December 2024
Department of Psychology, Harvard University, Cambridge, MA USA.
Unlabelled: Since the advent of smartphones, peer interactions over digital platforms have become a primary mode of socializing among adolescents. Despite the rapid rise in digital social activity, it remains unclear how this dramatic shift has impacted adolescent social and emotional experiences. In an intensive, longitudinal design ( = 26, = 206 monthly observations for up to 12 months, 12-17 years), we used digital phenotyping methods to objectively measure within-person fluctuations in smartphone use (screen time, pickups, notifications) across different categories (social media, communication, entertainment, games) and examined their prospective, bidirectional associations with positive and negative mood.
View Article and Find Full Text PDFDisentangling the relationship between biological age and frailty in community-dwelling older Mexican adults.
Gac Med Mex
November 2024
Research Division, Instituto Nacional de Geriatría, Mexico City, Mexico.
Background: Older adults have highly heterogeneous aging rates.
Objective: To explore the association of biological age (BA) and accelerated aging with frailty in community-dwelling older adults.
Methods: We assessed 735 community-dwelling older adults from the Coyocan Cohort.
Autism, intelligence, language, and adaptive behavior, disentangling a complex relationship.
Front Psychiatry
November 2024
Institute for Biomedical Research and Innovation (IRIB), National Research Council of Italy (CNR), Messina, Italy.
Introduction: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder characterized by a range of intellectual and language abilities. Its heterogeneity is acknowledged in modern diagnostics, complicating research and necessitating precision medicine and a multidimensional approach for individualized treatment and accurate assessment. Intellectual and language functioning influence adaptive skills and symptomatology.
View Article and Find Full Text PDFSoil properties drive nitrous oxide accumulation patterns by shaping denitrifying bacteriomes.
Environ Microbiome
November 2024
State Key Laboratory of Microbial metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Minhang District, Shanghai, 200240, China.
In agroecosystems, nitrous oxide (N₂O) emissions are influenced by both microbiome composition and soil properties, yet the relative importance of these factors in determining differential N₂O emissions remains unclear. This study investigates the impacts of these factors on N₂O emissions using two primary agricultural soils from northern China: fluvo-aquic soil (FS) from the North China Plain and black soil (BS) from Northeast China, which exhibit significant differences in physicochemical properties. In non-sterilized controls (NSC), we observed distinct denitrifying bacterial phenotypes between FS and BS, with BS exhibiting significantly higher N₂O emissions.
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