AI Article Synopsis
- A study investigated how leukopenia influences synovial white blood cell (WBC) counts and the percentage of neutrophils (%PMNs) in patients with septic arthritis.
- It compared synovial lab results of 79 non-leukopenic and 11 leukopenic patients, finding that leukopenic patients had significantly lower synovial WBC counts, but no significant difference in %PMNs.
- The findings suggest that traditional synovial WBC thresholds for diagnosing septic arthritis may not be effective for leukopenic patients.
Article Abstract
Background: It is not well-understood how leukopenia affects the synovial white blood cell (WBC) and percent neutrophils (%PMNs) in the setting of septic arthritis. We sought to determine 1. Do synovial WBC and %PMNs differ between patients with culture positive septic arthritis with or without leukopenia? And 2. Are traditional thresholds of synovial fluid studies for accurately diagnosing septic arthritis still applicable in the leukopenic patient population?
Methods: A retrospective cohort study was performed at a single institution of 79 non-leukopenic and 11 leukopenic patients diagnosed with culture-positive septic arthritis. Demographic data, serum laboratory values, synovial laboratory values, and culture results were recorded. Significant differences in synovial laboratory values were evaluated using the Wilcoxon-Mann-Whitney test. Results are reported as median, interquartile range, and values.
Results: There was a significant difference in synovial WBC in leukopenic patients compared to non-leukopenic patients with culture positive septic arthritis ( = 0.01). No significant difference was found in the synovial %PMNs between two cohorts ( = 0.33).
Conclusion: Leukopenic patients with culture positive septic arthritis have significantly lower synovial WBCs compared to non-leukopenic patients. Traditional thresholds for synovial WBC are not reliable for excluding diagnosis of septic arthritis in leukopenic patients.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108503 | PMC |
| http://dx.doi.org/10.1016/j.jor.2022.05.005 | DOI Listing |
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