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Short communication: The importance of random effects in detecting purging of inbreeding depression: A model comparison in Pannon White rabbits.
Animal
December 2024
Institute of Animal Sciences, Hungarian University of Agriculture and Life Sciences Institution, 40, Guba S. str., H-7400 Kaposvár, Hungary.
Inbreeding depression (ID) is a well-documented phenomenon associated with reduced fitness and possible extinction. However, ID can be mitigated or even eliminated through the interplay of inbreeding and selection, a process known as purging. The aim of this study was to compare the predictive power of two commonly used approaches in models with and without random dam effects to detect purging (full and reduced models).
View Article and Find Full Text PDFEnhancing equity in academic surgery promotion practices.
Surgery
January 2025
Section of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Chicago, Pritzker School of Medicine, IL. Electronic address:
Background: Black, Indigenous, People of Color (BIPOC) in medicine and women faculty have lower 10-year promotion rates than their White and male peers, despite controlling for productivity metrics. Promotion standards vary across institutions, but there is likely a common need to improve transparency and consistency while mitigating bias, inequity, and the harm of additional equity work that is commonly expected of Black, Indigenous, People of Color and women faculty (the so-called minority tax).
Methods: A promotion advisory committee consisting of clinical and research faculty at all ranks specified expectations for a faculty member at the associate or full professor ranks, with 10-15 examples given for each "mission" (clinical, research, and education).
Management of chimeric antigen receptor T-cell-related toxicity of a patient affected by cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, followed by an intestinal perforation: a case report.
J Med Case Rep
January 2025
Director of Hospital Pharmacy, Santa Croce e Carle Hospital, Cuneo, Italy.
Background: Mantle cell lymphoma is a diverse B-cell lymphoma with varying clinical behaviors. Treating relapsed or refractory mantle cell lymphoma is challenging, with Bruton's tyrosine kinase inhibitors proving effective but not curative. Post-Bruton's tyrosine kinase inhibitor failure, the prognosis remains unfavorable.
View Article and Find Full Text PDFSacubitril/valsartan attenuates inflammation and myocardial fibrosis in Takotsubo-like cardiomyopathy.
J Mol Cell Cardiol
January 2025
Department of Cardiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250031, PR China. Electronic address:
Background: Takotsubo syndrome (TTS) primarily manifests as a cardiomyopathy induced by physical or emotional stress, remains a poorly understood condition with no established treatments. In this study, we investigated the potential of sacubitril/valsartan (sac/val) to increase the survival of TTS patients and reduce inflammation and myocardial fibrosis in experimental models.
Aim: This study aimed to evaluate whether sac/val could improve survival rates in TTS patients, mitigate cardiac remodeling in vivo, and explore its anti-inflammatory and antifibrotic mechanisms in vitro.
Trajectory of Cognitive Decline Across Different Racial/Ethnic Groups: The Role of Edentulism.
Res Aging
January 2025
Rory Meyers College of Nursing, New York University, New York City, NY, USA.
This study examines whether age-related cognitive decline varies by race/ethnicity and how edentulism moderates these effects. Data from the Health and Retirement Study (2006-2020), including 23,669 respondents aged 51 and above across 189,352 person-wave observations were analyzed. Of all respondents, 13.
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