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Synthesis of Halopyrazole Matrine Derivatives and Their Insecticidal and Fungicidal Activities.

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CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), Guangzhou 510301, China.

Matrine is a traditional botanical pesticide with a broad-spectrum biological activity that is widely applied in agriculture. Halopyrazole groups are successfully introduced to the C13 of matrine to synthesize eight new derivatives with a yield of 78-87%. The insecticidal activity results show that the introduction of halopyrazole groups can significantly improve the insecticidal activity of matrine on , and with a corrected mortality rate of 100%, which is 25-65% higher than matrine.

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