AI Article Synopsis
- Gut microbiota significantly influences diseases like obesity, type 2 diabetes, heart failure, and non-alcoholic fatty liver disease.
- Polysaccharides from Chinese medicine have health benefits such as reducing inflammation, regulating immunity, and lowering blood sugar and lipids.
- The review discusses how these polysaccharides affect gut microbiota and highlights their potential as prebiotics in promoting health.
Article Abstract
The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity, type 2 diabetes mellitus, heart failure, and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory, regulating immunity, lowering blood glucose and lipids, anti-cancer, and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition, they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.
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| http://dx.doi.org/10.1007/s11655-022-3522-y | DOI Listing |
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