AI Article Synopsis
- - Psoriasis is a chronic condition that greatly affects quality of life, influenced by genetic and environmental factors, with no known cure but various treatment options available that often fail to control symptoms effectively.
- - A study evaluated 1,051 patients with moderate to severe psoriasis to determine factors linked to treatment failure, discovering associations with gender, type of therapy, age, treatment duration, and health-related quality of life.
- - Results indicate that males and those on biologic therapies are more likely to experience treatment failure, while older age and longer treatment duration reduce the likelihood of failure; additionally, higher DLQI scores correlate with increased risk of treatment failure.
Article Abstract
Background: Psoriasis is a chronic disease that seriously impacts quality of life. There are known genetic and environmental factors that influence its onset and progression. Even though there is no cure for it, there are a variety of treatments available today to control its symptoms, although many of them fail to do so substantially.
Objective: To identify the association of multiple sociodemographic, clinical, and pharmacological factors with therapeutic failure.
Methods: Observational, descriptive, cross-sectional, retrospective, and analytical study of therapeutic failure in patients with moderate or severe psoriasis between 2020 and 2021 was performed.
Results: In total 1051 patients with moderate or severe psoriasis were evaluated. Gender (ORa: 0.579 CI 95%: 0.382-0.878), type of therapy (biologic or non-biologic; ORa: 1.939 CI 95%: 1.242-3.027), age (ORa: 1.018 CI 95%: 1.003-1.034), days of treatment (ORa: 1 CI 95%: 0.999-1) and DLQI (ORa: 1.212 CI 95%: 1.172-1.253) are significantly associated with therapeutic failure.
Conclusion: Being male and receiving biologic therapy are associated with a higher incidence of therapeutic failure in the treatment of moderate or severe psoriasis. The increase in DLQI increase in the probability of failure, and mayor age or days of treatment decrease in the probability of failure.
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| http://dx.doi.org/10.1080/09546634.2022.2079597 | DOI Listing |
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