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A case for broadening our view of mechanism in developmental biology.
Development
January 2025
Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA.
Developmental biologists can perform studies that describe a phenomenon (descriptive work) and/or explain how the phenomenon works (mechanistic work). There is a prevalent perception that molecular/genetic explanations achieved via perturbations of gene function are the primary means of advancing mechanistic knowledge. We believe this to be a limited perspective, one that does not effectively represent the breadth of work in our field.
View Article and Find Full Text PDFReasons for retraction of clinical research articles in PubMed indexed medical journals from 2012 to 2022.
Indian J Med Ethics
January 2025
Department of Clinical Pharmacology, Toipwala National Medical College and BYL Nair Charitable Hospital, Mumbai 400008, Maharashtra, INDIA.
Background: Misconduct in the publication of research articles is a serious concern for the scientific community. This study was conducted with the objective to assess various reasons for retraction of clinical research articles published in PubMed indexed journals from all over the world since 2012 to 2022.
Methods: A search was performed on the PubMed database for retracted research articles using filters for "retracted publication".
Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression.
Clin Interv Aging
January 2025
Department of Neurology, the Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, People's Republic of China.
Purpose: Research suggests that insulin resistance (IR) is associated with acute ischemic stroke (AIS) and depression. The use of insulin-based IR assessments is complicated. Therefore, we explored the relationship between four non-insulin-based IR indices and post-stroke depression (PSD).
View Article and Find Full Text PDFPhysical Health Symptoms and Perceptions of Air Quality among Residents of Smoke-Damaged Homes from a Wildland Urban Interface Fire.
ACS EST Air
January 2025
Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz, Aurora, Colorado 80045, United States.
The Marshall Fire was a wildland urban interface (WUI) fire that destroyed more than 1000 structures in two communities in Colorado. High winds carried smoke and ash into an unknown number of buildings that, while not incinerated, were significantly damaged. We aimed to understand whether smoke or ash damage to one's home was associated with physical health impacts of the fire event for people living in and around the fire zone whose homes were not completely destroyed.
View Article and Find Full Text PDFCell type-specific upregulation of NKG2D ligand MICA in response to APTO253.
Ann Transl Med
December 2024
Institute for Tumor Immunology, Center for Tumor Biology and Immunology, Philipps-University Marburg, Marburg, Germany.
One of the most important targets for natural killer (NK) cell-mediated therapy is the induction of natural killer group 2D ligand (NKG2D-L) expression. APTO253 is a small molecule that selectively kills acute myeloid leukemia (AML) cells, and it has been reported that APTO253 can induce Krüppel-like factor 4 (KLF4) expression and downregulate c-MYC expression. Recently, we discovered a novel role of APTO253 in modulating the NK cell response by inducing surface expression of NKG2D-Ls, especially MHC class I polypeptide-related sequence A (MICA), in AML cells.
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