AI Article Synopsis
- Researchers developed zinc-peroxide nanoparticles coated with lipids and loaded with indocyanine green (ICG) to improve photodynamic therapy (PDT) in hypoxic tumors.
- The nanoparticles respond to near-infrared light (808 nm) by generating heat, which releases ZnO and induces tumor cell death.
- By producing oxygen in the tumor microenvironment, these nanoparticles enhance the effectiveness of PDT and help suppress tumor growth.
Article Abstract
The hypoxic nature of tumours limits the efficiency of oxygen-dependent photodynamic therapy (PDT). Hence, in this study, indocyanine green (ICG)-loaded lipid-coated zinc peroxide (ZnO) nanoparticles (ZnO@Lip-ICG) was constructed to realize tumour microenvironment (TME)-responsive self-oxygen supply. Near infrared light irradiation (808 nm), the lipid outer layer of ICG acquires sufficient energy to produce heat, thereby elevating the localised temperature, which results in accelerated ZnO release and apoptosis of tumour cells. The ZnO rapidly generates O in the TME (pH 6.5), which alleviates tumour hypoxia and then enhances the PDT effect of ICG. These results demonstrate that ZnO@Lip-ICG NPs display good oxygen self-supported properties and outstanding PDT/PTT characteristics, and thus, achieve good tumour proliferation suppression.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9091608 | PMC |
| http://dx.doi.org/10.1016/j.ajps.2022.01.002 | DOI Listing |
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