AI Article Synopsis
- The GFRα family receptors play a significant role in processes like cell growth, differentiation, migration, and tissue development.
- Evidence is discussed regarding the potential of GFRα signaling complexes as new targets for cancer treatment and overcoming treatment resistance.
- The review highlights the emerging importance of GFRα in cancer biology and suggests directions for future research in this field.
Article Abstract
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. Here we review GFRα biological functions and discussed the evidence indicating whether GFRα signaling complex present novel opportunities for oncogenic intervention and treatment resistance. Thus, our work systematically reviewed the emerging role of GFRα family members in cancers, and provided novel insights for further researches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9108399 | PMC |
| http://dx.doi.org/10.7150/ijms.64133 | DOI Listing |
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