Oral health aspects in sporadic and familial primary hyperparathyroidism.

Background: Primary hyperparathyroidism (pHPT) is the third most common endocrinopathy, affecting 1-3% of postmenopausal women, with a total incidence of 21.6 cases per 100,000 people in the adult population. This study aimed to analyze the oral health and related aspects of individuals with pHPT.

Material And Methods: A cross-sectional observational study was carried out on 51 patients diagnosed with pHPT associated with multiple endocrine neoplasia type 1 (MEN-1) (G1) or sporadic pHPT (G2). The oral aspects investigated were periodontal parameters, salivary flow, presence of dental caries, number of restored or missing teeth, and presence of tori. The biochemical parameters were collected in periods close to the dental evaluation.

Results: In G1, 29 individuals (19 females) aged 40.24±13.06 years were included; in G2, 22 individuals (21 females) aged 64.09±10.01 years were included. Grade 2 mobility (=0.031), mean probing depth (<0.001), loss of clinical insertion level (<0.001), gingival bleeding (=0.009), and presence of palatine tori (=0.007) were higher in G1. A higher mean of tooth loss (17.90±13.42; =0.031), teeth with active and/or inactive caries (<0.001), and visual change in enamel/enamel breakdown (<0.001) were also observed in G1. Most patients were 50 years old or younger, with a higher prevalence of older individuals in G2 (<0.001). G1 showed low socioeconomic status and G2 medium-high status (<0.001).

Conclusions: Despite the greater number of younger individuals, higher tooth loss and periodontal changes were observed in G1 patients. Differences in the degree of severity of pHPTor socioeconomic status alone could not explain these findings. Oral health, Primary hyperparathyroidism, Multiple endocrine neoplasia type 1, osteopenia, osteoporosis.