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| http://dx.doi.org/10.9740/mhc.2022.04.054 | DOI Listing |
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Protective Antimicrobial Effect of the Potential Vaccine Created on the Basis of the Structure of the IgA1 Protease from .
Vaccines (Basel)
November 2024
Laboratory of Proteolytic Enzyme Chemistry, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 117997 Moscow, Russia.
IgA1 protease is one of the virulence factors of , and other pathogens causing bacterial meningitis. The aim of this research is to create recombinant proteins based on fragments of the mature IgA1 protease A-P from serogroup B strain H44/76. These proteins are potential components of an antimeningococcal vaccine for protection against infections caused by pathogenic strains of and other bacteria producing serine-type IgA1 proteases.
View Article and Find Full Text PDFCharacterization of Dendritic Cells and Myeloid-Derived Suppressor Cells Expressing Major Histocompatibility Complex Class II in Secondary Lymphoid Organs in Systemic Lupus Erythematosus-Prone Mice.
Int J Mol Sci
December 2024
Millennium Institute on Immunology and Immunotherapy, Laboratorio de Inmunología Traslacional, Departamento de Ciencias Biológicas, Facultad de Ciencias de la Vida, Universidad Andrés Bello, Santiago 8370133, Chile.
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by self-antibody production and widespread inflammation affecting various body tissues. This disease is driven by the breakdown of immune tolerance, which promotes the activation of autoreactive B and T cells. A key feature of SLE is dysregulation in antigen presentation, where antigen-presenting cells (APCs) play a central role in perpetuating immune responses.
View Article and Find Full Text PDF[The exploratory meeting: Action research on the perspective of care recipients].
Tijdschr Psychiatr
January 2025
Background: Mental health care (MHC) is under pressure due to increased demands and limited capacity, resulting in long waiting lists. To improve accessibility, Mental Health Centers (MCs) were established in Central and West-Brabant starting in 2021, with the exploratory meeting (EM) as the first step.
Aim: To gain insight into citizens’ experiences with the EM, the flow to appropriate care, and contribution of action research to this process.
Geometric deep learning improves generalizability of MHC-bound peptide predictions.
Commun Biol
December 2024
Medical BioSciences department, Radboudumc, Radboud University Medical Center, 6525 GA, Nijmegen, The Netherlands.
Article Synopsis
- The interaction between peptides and MHC molecules is crucial for understanding autoimmunity and improving cancer immunotherapies.
- Recent advancements reveal that traditional sequence-based prediction methods have limitations, prompting the need for better approaches.
- The new structure-based methods, utilizing geometric deep learning and self-supervised learning, show improved accuracy and efficiency in predicting MHC-bound peptides, even outperforming conventional methods with significantly less data.
Complement C3d enables cell-mediated immunity capable of distinguishing spontaneously transformed from nontransformed cells.
Proc Natl Acad Sci U S A
December 2024
Department of Surgery, University of Michigan, Ann Arbor, MI 48109.
Immune surveillance depends in part on the recognition of peptide variants by T cell antigen receptors. Given that both normal B cells and malignant B cells accumulate mutations we chose a murine model of multiple myeloma to test conditions to induce cell-mediated immunity targeting malignant plasma cell (PC) clones but sparing of normal PCs. Revealing a previously unknown function for intracellular C3d, we found that C3d engaged T cell responses against malignant PC in the bone marrow of mice that had developed multiple myeloma spontaneously.
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