AI Article Synopsis
- Pharmacogenetics explores how an individual's genetic makeup influences their response to drugs, especially in the context of monoclonal antibodies (mAbs) used in cancer therapy.
- Since the introduction of Rituximab in 1997, mAbs have become a leading method in cancer treatment, with several new and effective options emerging.
- The effectiveness of mAb therapies can vary greatly based on genes related to antibody presentation and metabolism, highlighting the importance of studying patient genetics to optimize treatment outcomes.
Article Abstract
Pharmacogenetics is the study of therapeutic and adverse responses to drugs based on an individual's genetic background. Monoclonal antibodies (mAbs) are a rapidly evolving field in cancer therapy, however a number of newly developed and highly effective mAbs (e.g., anti-CTLA-4 and anti-PD-1) possess pharmacogenomic profiles that remain largely undefined. Since the first chemotherapeutic mAb Rituximab was approved in 1997 by the US Food and Drug Administration for cancer treatment, a broad number of other mAbs have been successfully developed and implemented into oncological practice. Nowadays, mAbs are considered as one of the most promising new approaches for cancer treatment. The efficacy of mAb treatment can however be significantly affected by genetic background, where genes responsible for antibody presentation and metabolism, for example, can seriously affect patient outcome. This review will focus on current anticancer mAb treatments, patient genetics that shape their efficacy, and the molecular pathways that bridge the two.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019180 | PMC |
| http://dx.doi.org/10.20517/cdr.2018.20 | DOI Listing |
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