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Pseudocellulitis in the Setting of Pemetrexed Treatment for Non-Small Cell Lung Cancer.
J Cutan Pathol
January 2025
Division of Dermatology, The University of Texas at Austin, Dell Medical School, Austin, Texas, USA.
Pemetrexed is a chemotherapeutic, antimetabolite agent that has been used in oncology to treat diseases such as metastatic non-small cell lung cancer and unresectable malignant pleural mesothelioma. Pemetrexed use may result in pseudocellulitis, which presents as poorly demarcated patches or plaques with erythema, edema, warmth, and tenderness. These lesions can present unilaterally or bilaterally on the lower extremities.
View Article and Find Full Text PDFEccrine poroma versus eccrine porocarcinoma: a comparative study of clinicopathological features.
An Bras Dermatol
December 2024
Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm, commonly arising from its benign counterpart, eccrine poroma (EP), but potential unrevealed clinicopathological differences between them are not well understood.
Objectives: This study aimed to identify clinicopathological features of EP and EPC and describe the factors that may be associated with the malignant transformation of EP by comparing the two groups.
Methods: A total of 37 cases of EP and 22 cases of EPC diagnosed between January 2017 and June 2023 were retrospectively reviewed, and the clinical and histopathological characteristics were compared using statistical methods.
Diagnosis and Management of Malignant Epithelial Nail Unit Tumors.
Diagnostics (Basel)
October 2024
Dermatology Department, Saint Pierre and Brugmann University Hospitals, Université Libre de Bruxelles, 1000 Brussels, Belgium.
Article Synopsis
- Malignant tumors of the nail unit, like squamous cell carcinoma and basal cell carcinoma, can be hard to diagnose because they often look like benign issues, making early detection important.
- * This review examines various types of malignancies affecting the nail unit, discussing their clinical features, pathology, and surgical management challenges.
- * Proper evaluation and treatment strategies are critical for improving patient outcomes and preserving nail function during surgery.*
Familiar cylindromatosis in a Colombian family caused by a mutation in CYLD.
Ecancermedicalscience
September 2024
Department of Human Genetics, Fundación Valle del Lili, Cali 760026, Colombia.
Article Synopsis
- The CYLD cutaneous syndrome leads to multiple skin tumors like cylindromas and spiradenomas, primarily affecting the face and head, with more frequent occurrence in women.
- A Colombian family spanning three generations showcased early onset of this syndrome, confirmed by genetic analysis identifying a specific variant in the CYLD gene.
- Understanding the genetic and environmental factors behind the syndrome is vital for developing better treatments and enhancing patient care.
Poroid Neoplasms: A Clinicopathological Study of 13 Cases.
Clin Pathol
September 2024
Faculty of Health Sciences, Abdou Moumouni University, Niamey, Niger.
Article Synopsis
- Poroid neoplasms (PN) are diverse tumors that originate from sweat glands, and their classification and identifying features can be difficult.
- A study conducted at the Niamey National Hospital from February 2020 to February 2024 found 13 cases of benign poroid neoplasms, mostly classic poromas, with a majority being misdiagnosed as malignant before surgery.
- The results indicate that these tumors often have apocrine ductal features and tend to occur in younger patients and non-palmoplantar areas, challenging traditional understandings of their characteristics.
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