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The Gut Microbiome in Colorectal Cancer. | LitMetric

The Gut Microbiome in Colorectal Cancer.

Hematol Oncol Clin North Am

Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, 1825 4th Street, PCMB 4 (L4141), Box 1705, San Francisco, CA 94143, USA; Helen Diller Family Comprehensive Cancer Center, 1450 3rd St, San Francisco, CA 94158, USA.

Published: June 2022

AI Article Synopsis

Article Abstract

The gut microbiome is important in human health and disease. Recent studies have begun to elucidate its specific role in colorectal cancer. The gut microbiome seems to play an integral role in colorectal cancer initiation and progression, and oncologic drug metabolism and toxicity. This review examines the associations between the gut microbiome and colorectal cancer initiation, progression, and oncologic drug metabolism, highlighting proposed mechanisms and landmark publications in this field. It also discusses potential methods of modulating the gut microbiome, underscoring the gaps in current understanding, and ends with a clinically relevant overview of microbiome research considerations and study design.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.hoc.2022.03.001DOI Listing

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