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Donor Regulatory T-Cell Therapy to Prevent Graft-Versus-Host Disease.
Blood
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Stanford University Medical Center, Stanford, California, United States.
Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy limited by graft-versus-host disease (GVHD). In preclinical studies and early-phase clinical studies enrichment of donor regulatory T cells (Tregs) appears to prevent GVHD and promote healthy immunity.We enrolled 44 patients on an open-label, single-center, phase 2 efficacy study investigating if a precision selected and highly purified Treg cell therapy manufactured from donor mobilized peripheral blood improves one-year GVHD-free relapse free survival (GRFS) after myeloablative conditioning (trial NCT01660607).
View Article and Find Full Text PDFSex-Specific Difference in Health-Related Altitude-Effects and Their Prevention by Acetazolamide. Data from a Randomized Controlled Trial.
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Department of Respiratory Medicine, University Hospital Zurich, Zurich, Switzerland.
Häfliger, Alina, Aline Buergin, Laura C. Mayer, Maamed Mademilov, Mona Lichtblau, Talantbek Sooronbaev, Silvia Ulrich, Konrad E. Bloch, and Michael Furian.
View Article and Find Full Text PDFDistal Triceps Tendon Rupture-First Retrospective Study in Central Europe.
J Clin Med
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Clinic of Oncology and Surgery, Faculty of Medecine, Comenius University, 81250 Bratislava, Slovakia.
This retrospective study is the only one in the last 10 years from central Europe and provides a current picture of prevalence, new diagnostic modalities, new methods of surgical treatment, and also offers new insights into post-operative care. Triceps tendon rupture is the least reported among all the tendon injuries in the literature. In general, effective treatments for tendon injuries are lacking because the understanding of tendon biology lags behind that of the other components of the musculoskeletal system.
View Article and Find Full Text PDFAcute and Lifelong Endurance Exercise Yields Differential Effects During Circadian Disruption in Mice.
Med Sci Sports Exerc
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Department of Zoology and Physiology, Program in Neuroscience, University of Wyoming, Laramie, WY.
Introduction: Circadian rhythms are responsible for physiological and behavioral processes coordinated in a 24-hour cycle. We investigated whether untimed, long-term voluntary wheel access mitigated circadian disruption and facilitated re-entrainment. Methods: Thirty-four C57Bl/6 J mice (n = 21 males, n = 14 females) were used in this experiment.
View Article and Find Full Text PDFHigh Altitude Pulmonary Edema Associated with Climbing Mount Fuji: A Case Report.
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Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University School of Medicine, Japan.
A 51-year-old man presented to the emergency department with rapidly progressive dyspnea that developed while climbing Mount Fuji. He had climbed Mount Fuji twice without experiencing similar symptoms. On arrival, his oxygen saturation was 91% on 10 L/min of oxygen with a non-rebreather mask.
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