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| http://dx.doi.org/10.1136/bcr-2022-250056 | DOI Listing |
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Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and genotype.
PNAS Nexus
January 2025
Faculty of Health and Life Sciences, University of Exeter Medical School, University of Exeter, St Luke's campus, Exeter EX1 2LU, United Kingdom.
Apolipoprotein () genotype and nitric oxide (NO) deficiency are risk factors for age-associated cognitive decline. The oral microbiome plays a critical role in maintaining NO bioavailability during aging. The aim of this study was to assess interactions between the oral microbiome, NO biomarkers, and cognitive function in 60 participants with mild cognitive impairment (MCI) and 60 healthy controls using weighted gene co-occurrence network analysis and to compare the oral microbiomes between carriers and noncarriers in a subgroup of 35 MCI participants.
View Article and Find Full Text PDFMultiscale Analysis of Alzheimer's Disease Using Feature Fusion in Cognitive and Sensory Brain Regions.
Digit Biomark
December 2024
Electrical and Computer Engineering, Western Michigan University, Kalamazoo, MI, USA.
Introduction: This research is focused on early detection of Alzheimer's disease (AD) using a multiscale feature fusion framework, combining biomarkers from memory, vision, and speech regions extracted from magnetic resonance imaging and positron emission tomography images.
Methods: Using 2D gray level co-occurrence matrix (2D-GLCM) texture features, volume, standardized uptake value ratios (SUVR), and obesity from different neuroimaging modalities, the study applies various classifiers, demonstrating a feature importance analysis in each region of interest. The research employs four classifiers, namely linear support vector machine, linear discriminant analysis, logistic regression (LR), and logistic regression with stochastic gradient descent (LRSGD) classifiers, to determine feature importance, leading to subsequent validation using a probabilistic neural network classifier.
Grazing Intensity Modifies Soil Microbial Diversity and Their Co-Occurrence Networks in an Alpine Steppe, Central Tibet.
Microorganisms
January 2025
Lhasa Plateau Ecosystem Research Station, Key Laboratory of Ecosystem Network Observation and Modeling, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
Grazing intensity is one of the crucial anthropogenic activities on alpine grasslands. However, how grazing intensity affects soil microorganism diversities and their co-occurrence networks in alpine steppe remains uncertain. We carried out a controlled grazing experiment (null grazing, CK; moderate grazing, MG; and heavy grazing, HG) on a typical alpine steppe in the Lhasa River Basin, Central Tibet, China.
View Article and Find Full Text PDFOculomotor Function in Children and Adolescents with Autism, ADHD or Co-occurring Autism and ADHD.
J Autism Dev Disord
January 2025
School of Psychological Sciences, Monash University, 18 Innovation Walk, Melbourne, VIC, 3800, Australia.
Oculomotor characteristics, including accuracy, timing, and sensorimotor processing, are considered sensitive intermediate phenotypes for understanding the etiology of neurodevelopmental conditions, such as autism and ADHD. Oculomotor characteristics have predominantly been studied separately in autism and ADHD. Despite the high rates of co-occurrence between these conditions, only one study has investigated oculomotor processes among those with co-occurring autism + ADHD.
View Article and Find Full Text PDFStudy on the synergistic mechanisms of fungal biodiversity and ecosystem multifunctionality across vegetation diversity gradients.
Sci Total Environ
January 2025
College of Biological Sciences and Technology, Taiyuan Normal University, Jinzhong 030619, China.
Ecosystem multifunctionality denotes the capacity of an ecosystem to deliver various functions and services concurrently, emphasizing the overall effectiveness of these functions. Although biodiversity is intrinsically linked to ecosystem multifunctionality, research on the determinants of changes in this relationship remains limited. This study focused on 147 research plots across various ecosystems in the Lüliang region.
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