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The importance of mechanical and biological cues of tympanic membrane grafts to ensure optimal regeneration.
Biomater Adv
May 2024
Polymer Chemistry and Biomaterials Group (PBM), Centre of Macromolecular Chemistry (CMaC), Ghent University, 9000 Ghent, Belgium. Electronic address:
Chronic suppurative otitis media (CSOM) is often associated with permanent tympanic membrane (TM) perforation and conductive hearing loss. The current clinical gold standard, using autografts and allografts, suffers from several drawbacks. Artificial replacement materials can help to overcome these drawbacks.
View Article and Find Full Text PDFEffectiveness of Infliximab in Patients with Complex Regional Pain Syndrome: A Case Series.
J Pain Res
June 2023
Department of Anesthesiology, Center for Pain Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Purpose: Complex regional pain syndrome (CRPS) is a multi-mechanism disease, with an exaggerated inflammatory response as an important underlying mechanism. Auto-inflammation can theoretically be combated by anti-inflammatories, such as TNF-α inhibitors. This study's aim was to assess the effectiveness of intravenous infliximab, a TNF-α inhibitor, in patients with CRPS.
View Article and Find Full Text PDFIntermittent versus continuous esketamine infusions for long-term pain modulation in complex regional pain syndrome: protocol of a randomized controlled non-inferiority study (KetCRPS-2).
BMC Musculoskelet Disord
March 2023
Department of Anesthesiology, Center for Pain Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- Complex regional pain syndrome (CRPS) is a tough condition that causes long-lasting pain in arms or legs, and some people might feel better after getting esketamine treatment.
- This study compares two ways to give esketamine: one method is a long, continuous treatment in a hospital, and the other is shorter treatments done every two weeks at home.
- The goal is to see if the home treatment works just as well as the hospital one, while also checking how safe and cost-effective these treatments are for patients.
Finite element modelling of the human middle ear using synchrotron-radiation phase-contrast imaging.
Comput Biol Med
May 2023
Department of Electrical and Computer Engineering, Western University, London, Ontario, Canada; Department of Medical Biophysics, Western University, London, Ontario, Canada; Department of Otolaryngology - Head and Neck Surgery, Western University, London, Ontario, Canada.
Finite element (FE) models of the middle ear often lack accurate geometry of soft tissue structures, such as the suspensory ligaments, as they can be difficult to discern using conventional imaging modalities, such as computed tomography. Synchrotron-radiation phase-contrast imaging (SR-PCI) is a non-destructive imaging modality that has been shown to produce excellent visualization of soft tissue structures without the need for extensive sample preparation. The objectives of the investigation were to firstly use SR-PCI to create and evaluate a biomechanical FE model of the human middle ear that includes all soft tissue structures, and secondly, to investigate how modelling assumptions and simplifications of ligament representations affect the simulated biomechanical response of the FE model.
View Article and Find Full Text PDFBlowing pressure stabilization method for the artificial excitation of reed instruments (L).
J Acoust Soc Am
February 2023
Department of Physics, Laboratory of Biomedical Physics BIMEF, University of Antwerp, Groenenborgerlaan 171, Antwerp, 2020, Belgium.
To investigate the acoustics of reed instruments without the need for a human player, blowing machines are needed, which can generate air pressures up to 8 kPa and flow rates up to 40 liters per minute. Due to reed flexibility and the changing pressure gradient across the reed, the relationship between flow and pressure is highly non-linear. Since the output pressure of ventilators is highly dependent on flow, non-linear pressure regulation is a difficult task that requires a closed-loop approach.
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