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| http://dx.doi.org/10.1016/j.jinf.2022.05.008 | DOI Listing |
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New endocrine method of oral male contraception.
Contraception
December 2024
R&D Department, Pandora Endocrine Innovation, Bergen, Netherlands. Electronic address:
Essential for hormonal male contraception (HMC) is the inhibition of follicle-stimulating hormone (FSH), the hormone responsible for spermatogenesis. No drugs exist that can selectively suppress FSH without also inhibiting luteinizing hormone (LH), the hormone responsible for the biosynthesis of testosterone (T) and estradiol (E2) in men. The consequences are a loss of T and E2, with the accompanying symptoms and signs of T deficiency and E2 deficiency, respectively.
View Article and Find Full Text PDFBackground: Although sex differences in coronary artery disease (CAD) risk have been observed, little is known about the role of sex hormones in CAD genetics. Accounting for sex hormone levels may help identify CAD-risk loci and extend our knowledge of its genetic architecture.
Methods And Results: A total of 365 662 individuals of European ancestry enrolled in the UK Biobank were considered.
Association Between Female Androgen Levels, Metabolic Syndrome, and Cardiovascular Disease: An NHANES Analysis (2013-2016).
Int J Womens Health
December 2024
Department of Obstetrics and Gynecology, Zhongda Hospital, Nanjing, Jiangsu, People's Republic of China.
Background: The impact of androgens on metabolic diseases, cardiovascular diseases (CVD), and long-term mortality in the general female population remains poorly understood. This study, utilizing data from the National Health and Nutrition Examination Survey (NHANES) database managed by the Centers for Disease Control and Prevention, seeks to elucidate the relationship between androgen levels and metabolic syndrome (MS), CVD, and mortality in adult women.
Methods: After excluding ineligible individuals, descriptive analyses were conducted on demographic characteristics, metabolic-related indicators, and disease prevalence, based on the presence of high androgenemia and androgen quartile grouping.
Optimizing Testosterone Levels and Fertility Outcomes: A Case Series on the Impact of (Maca-OG) in Andropause and Sperm Dysfunction.
Am J Mens Health
December 2024
Symphony Natural Health, West Lake City, UT, USA.
Low testosterone levels in men contribute to altered sexual health, including low libido, erectile dysfunction, impaired sleep, and changes in mood and energy. Nearly half of all infertility cases are implicated by male factors, such as low testosterone levels and altered semen and sperm health. The purpose of this case series is to share the experience of two men taking a concentrated, highly bioavailable gelatinized form of specific phenotypes (sometimes referred to as colors) of (Maca-OG™) to improve reproductive health.
View Article and Find Full Text PDFEvaluation of dimethandrolone undecanoate in non-human primates as a candidate for long-acting injectable male contraceptive.
Andrology
December 2024
Contraceptive Development Program, Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, Maryland, USA.
Background: Dimethandrolone undecanoate (DMAU) is under development as a single agent hormonal male contraceptive. DMAU is a prodrug hydrolyzed by esterase(s) to the active metabolite dimethandrolone (DMA) which has dual androgenic and progestogenic actions. Phase 1 clinical trial results show DMAU to be well-tolerated as an oral contraceptive in healthy men; however, delivery of DMAU as a long-acting injectable rather than a daily oral formulation would provide user compliance benefits and address oral bioavailability concerns.
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