• The structure of glycoprotein Gc, responsible for membrane fusion, is revealed, but many more mysteries remain. • Why do only antibodies against Gc have neutralizing effect, but not the one against Gn? • Why can NAbs against Gc only be protective in the animals in preventive settings, but not in the therapeutic administration?
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http://dx.doi.org/10.1016/j.virs.2022.05.003 | DOI Listing |
Sci Rep
January 2025
International Livestock Research Institute (ILRI), Human and Animal Health, Berlin, Germany.
Crimean Congo hemorrhagic fever (CCHF) is a re-emerging tick-borne zoonosis that is caused by CCHF virus (CCHFV). The geographical distribution of the disease and factors that influence its occurrence are poorly known. We analysed historical records on its outbreaks in various countries across the sub-Saharan Africa (SSA) to identify hotspots and determine socioecological and demographicfactors associated with these outbreaks.
View Article and Find Full Text PDFCell
January 2025
Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address:
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tickborne virus that can cause severe disease in humans with case fatality rates of 10%-40%. Although structures of CCHFV glycoproteins GP38 and Gc have provided insights into viral entry and defined epitopes of neutralizing and protective antibodies, the structure of glycoprotein Gn and its interactions with GP38 and Gc have remained elusive. Here, we use structure-guided protein engineering to produce a stabilized GP38-Gn-Gc heterotrimeric glycoprotein complex (GP38-Gn-Gc).
View Article and Find Full Text PDFJ Infect Public Health
January 2025
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with a Case Fatality Ratio (CFR) of 10-40 %. It spreads from livestock to humans primarily through tick bites. It is crucial to monitor the peak months of this endemic disease in Afghanistan.
View Article and Find Full Text PDFParasit Vectors
November 2024
Faculty of Science, Department of Molecular Biology and Genetics, Koc University, 34450, Ýstanbul, Türkiye.
Background: Ticks are crucial vectors of a wide range of pathogens, posing significant threats to human and animal health globally. Understanding the genetic basis of tick biology and host-parasite interactions is essential for developing effective control programs. This study investigates the fine-scale genetic structure of Hyalomma marginatum Koch, 1844, the primary vector of Crimean-Congo hemorrhagic fever (CCHF) in Türkiye.
View Article and Find Full Text PDFCurr Res Parasitol Vector Borne Dis
October 2024
Joint Research Unit Animal, Health, Territories, Risks, Ecosystems (UMR ASTRE), French Agricultural Research Centre for International Development (CIRAD), National Research Institute for Agriculture, Food and Environment (INRAE), Montpellier, France.
Ticks are important zoonotic disease vectors for human and animal health worldwide. In Europe they are the principal vector of public health importance, responsible for Lyme disease, the most prevalent and widespread tick-borne disease (TBD). Tick presence and TBD incidence are increasing, questioning the effectiveness of existing surveillance systems.
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