To explore the lower efficacy of adoptive cell transfer (ACT) therapy in patients with anti-PD-1 experienced melanoma, tumor mutational burden (TMB), predicted neoantigen frequencies, and tumor-infiltrating lymphocyte (TIL) neoantigen reactivity were assessed. Reduced neoantigen-specific TIL frequencies correlated with lower ACT response even in patients with similar TMB, suggesting a potentially harmful effect of PD-1 inhibition on T-cell outgrowth. See related article by Levi et al., p. 3042.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9288489 | PMC |
| http://dx.doi.org/10.1158/1078-0432.CCR-22-0832 | DOI Listing |
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