LncRNA , a Ferroptosis Suppressor and Prognositic Signature for GBM.

is a long noncoding RNA also known as long intergenic nonprotein coding RNA 1272 (). The known reports showed that functions as an onco-lncRNA or a suppressor lncRNA by suppressing miRNA in colorectal cancer, gastric cancer and lung cancer. In this study, we first found that , as an onco-lncRNA, alleviates the ferroptosis driven by mutant and promotes mutant -mediated GBM proliferation. We also first confirmed that is a new ferroptosis suppressor lncRNA that functions as a ferroptosis inhibitor mainly by mutant mediating the ROS ferroptosis pathway, which inhibits the production of ROS, reduces the levels of divalent iron ions, promotes the expression of , and inhibits the expression of and . can inhibit the expression of in wild-type GBM cells and regulate the expression of and , but it has no effect on , and in mutant GBM cells. and can form a complex through the RNA binding protein EIF4A3. Knockdown of resulted in smaller mitochondria, increased mitochondrial membrane density, and enhanced sensitivity to ferroptosis inducers to inhibit GBM cell proliferation and invasion. In addition, we established a favourite prognostic model with and . is a promising target for the prognosis and treatment of GBM.