A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3098
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: Attempt to read property "Count" on bool

Filename: helpers/my_audit_helper.php

Line Number: 3100

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3100
Function: _error_handler

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Toward dynamic, anisotropic, high-resolution, and functional measurement in the brain extracellular space. | LitMetric

Diffusion of substances in the brain extracellular space (ECS) is important for extrasynaptic communication, extracellular ionic homeostasis, drug delivery, and metabolic waste clearance. However, substance diffusion is largely constrained by the geometry of brain ECS and the extracellular matrix. Investigating the diffusion properties of substances not only reveals the structural information of the brain ECS but also advances the understanding of intercellular signaling of brain cells. Among different techniques for substance diffusion measurement, the optical imaging method is sensitive and straightforward for measuring the dynamics and distribution of fluorescent molecules or sensors and has been used for molecular diffusion measurement in the brain. We mainly discuss recent advances of optical imaging-enabled measurements toward dynamic, anisotropic, high-resolution, and functional aspects of the brain ECS diffusion within the last 5 to 10 years. These developments are made possible by advanced imaging, such as light-sheet microscopy and single-particle tracking in tissue, and new fluorescent biosensors for neurotransmitters. We envision future efforts to map the ECS diffusivity across the brain under healthy and diseased conditions to guide the therapeutic delivery and better understand neurochemical transmissions that are relevant to physiological signaling and functions in brain circuits.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9094757PMC
http://dx.doi.org/10.1117/1.NPh.9.3.032210DOI Listing

Publication Analysis

Top Keywords

brain ecs
12
brain
9
dynamic anisotropic
8
anisotropic high-resolution
8
high-resolution functional
8
measurement brain
8
brain extracellular
8
extracellular space
8
substance diffusion
8
diffusion measurement
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!