Antioxidant, Anti-Inflammatory, and Digestive Enzymes Inhibition Activities of Hydro-Ethanolic Leaf and Bark Extracts of (K. Krause) Verdc.

hydro-ethanolic leaf extract (PHELE) and bark extract (PHEBE) were evaluated for antioxidant, anti-inflammatory, and inhibition of digestive enzymes activities. The antioxidant activity was characterized by 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), ferric reducing antioxidant power (FRAP), total phenolic content (TPC), and total flavonoid content (TFC) assays. The anti-inflammatory activity was characterized by protein denaturation and antiproteinase tests, while the inhibition of the enzymes was assessed using -amylase, -glucosidase, lipase, and cholesterol esterase activities. PHELE presented low ( < 0.001) IC (59.09 ± 5.97 g/ml) for DPPH compared with ascorbic acid (71.78 ± 6.37 g/ml) and (115.40 ± 1.21 g/ml). The IC of (262.4 ± 4.46 g/ml) and (354.2 ± 1.97 g/ml) was higher ( < 0.001) than that of catechin (33.48 ± 2.02 g/ml) for ABTS. had high ( < 0.001) FRAP (341.73 ± 21.70 mg CE/g) than (150.30 ± 0.32 mg CE/g). presented ( < 0.001) high TPC (270.05 ± 7.53 mg CE/g) and TFC (23.43 ± 0.032 mg CE/g) than (TPC: 138.89 ± 0.91 and TFC: 20.06 ± 0.032 mg CE/g). showed antiprotein denaturation with IC (257.0 ± 7.51 g/ml) ( < 0.001) and antiproteinase activity (74.37 ± 1.10 g/ml) lower than (316.1 ± 6.02 g/ml and 177.6 ± 0.50 g/ml), respectively. Orlistat inhibited lipase ( < 0.001) activity with IC (37.11 ± 4.39 g/ml) lower than and (50.57 ± 2.89 g/ml and 62.88 ± 1.74 g/ml, respectively). inhibited cholesterol esterase with IC (34.75 ± 3.87 g/ml) lower than orlistat (54.61 ± 2.56) and (80.14 ± 1.71 g/ml). inhibited -amylase IC (6.07 ± 4.05 g/ml) lower than (19.69 ± 6.27 g/ml) and acarbose (20.01 ± 2.84 g/ml). Acarbose inhibited -glucosidase ( < 0.001) activity with IC (4.11 ± 3.47 g/ml) lower than (24.41 ± 2.84 g/ml) and (38.81 ± 2.46 g/ml). presented better antioxidant, anti-inflammatory, and enzyme inhibition activity than PHEBE.