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| http://dx.doi.org/10.3389/fchem.2022.908165 | DOI Listing |
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Effects of 5-ion 6-beam sequential irradiation in the presence and absence of hindlimb or control hindlimb unloading on behavioral performances and plasma metabolic pathways of Fischer 344 rats.
Front Physiol
November 2024
Radiation Biosciences laboratory, Medical College of Wisconsin, Milwaukee, WI, United States.
Article Synopsis
- The study investigates how microgravity and galactic cosmic rays (GCRs) influence behavioral performance and metabolic pathways in male Fischer rats, highlighting a gap in previous research regarding control conditions for hindlimb unloading (HU).
- Male rats were subjected to total body irradiation and HU conditions, with plasma and brain tissue analyzed after 6 months to assess long-term metabolic changes.
- Results showed significant interactions between radiation and HU, with various metabolic pathways affected in the plasma and brain, indicating complex interactions between stressors that could impact spaceflight crew health.
RadLab: An open science resource for radiation studies relevant to human spaceflight.
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November 2024
Space Biosciences Research Branch, NASA Ames Research Center, Moffett Field, CA. Electronic address:
In response to the growing need of the space life sciences community for a publicly available single access point for radiation physics data relevant to human space exploration, an open data repository and analysis platform, RadLab, has been developed. RadLab consists of a database and a user-friendly data retrieval, visualization, and analysis toolkit, including a graphical user interface (GUI) and an application programming interface (API). RadLab complements the space biology data in the NASA Open Science Data Repository (OSDR) and aims to provide open, centralized access to radiation physics data relevant to spaceflight.
View Article and Find Full Text PDFBeyond Earth's shield: The surprising way antioxidants could pave the road to Mars.
J Neurochem
January 2025
Facultad de Ciencias, Instituto de Física, Universidad de la República, Montevideo, Uruguay.
Interplanetary travel poses serious risks because of Galactic cosmic radiations (GCRs). A recent study by Sanghee et al. revealed long-term cognitive impairments in female mice exposed to a 33-beam GCR simulator, highlighting persistent risks for astronauts.
View Article and Find Full Text PDFEvaluation of deep space exploration risks and mitigations against radiation and microgravity.
Front Nucl Med
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Radiobiology Unit, Belgian Nuclear Research Centre (SCK CEN), Mol, Belgium.
Ionizing radiation and microgravity are two considerable health risks encountered during deep space exploration. Both have deleterious effects on the human body. On one hand, weightlessness is known to induce a weakening of the immune system, delayed wound healing and musculoskeletal, cardiovascular, and sensorimotor deconditioning.
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