AI Article Synopsis
- The study investigates how Vitamin D3 (VD3) may help combat both stomach adenocarcinoma (STAD) and COVID-19, highlighting its antiviral, anti-inflammatory, and immunomodulatory properties.
- Through clinicopathological and bioinformatics analyses, the researchers identified key characteristics of patients and potential mechanisms of VD3's action against these diseases.
- Molecular docking results demonstrated that VD3 effectively binds to important targets in COVID-19, suggesting its potential as a therapeutic option for patients with both STAD and COVID-19.
Article Abstract
The persistent pandemic of coronavirus disease 2019 (COVID-19), the discovery of gastrointestinal transmission routes and the possible susceptibility of cancer patients to COVID-19 have forced us to search for effective pathways against stomach adenocarcinoma (STAD)/COVID-19. Vitamin D3 (VD3) is a steroid hormone with antiviral, anti-inflammatory and immunomodulatory properties. This study aimed to evaluate the possible functional role and potential mechanisms of action of VD3 as an anti-COVID-19 and anti- STAD. Clinicopathological analysis, enrichment analysis and protein interaction analysis using bioinformatics and network pharmacology methods. Validate the binding activity of VD3 to core pharmacological targets and viral crystal structures using molecular docking. We revealed the clinical characteristics of STAD/COVID-19 patients. We also demonstrated that VD3 may be anti- STAD/COVID-19 through antiviral, anti-inflammatory, and immunomodulatory pathways. Molecular docking results showed that VD3 binds well to the relevant targets of COVID-19, including the spike RBD/ACE2 complex and main protease (Mpro, also known as 3CLpro). We also identified five core pharmacological targets of VD3 in anti-STAD/COVID-19 and validated the binding activity of VD3 to PAI1 by molecular docking. This study reveals for the first time that VD3 may act on disease target gene through inflammatory and viral related signaling pathways and biological functions for the therapy of STAD/COVID-19. This may provide a new idea for the use of VD3 in the treatment of STAD/COVID-19.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095980 | PMC |
| http://dx.doi.org/10.3389/fphar.2022.874637 | DOI Listing |
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