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CRISPR-Cas9 Cytidine-Base-Editor Mediated Continuous Evolution in .
ACS Synth Biol
January 2025
College of Life Science, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271016, China.
Filamentous fungi are important cell factories for producing chemicals, organic acids, and enzymes. Although several genome editing tools are available for filamentous fungi, few effectively enable continuous evolution for rational engineering of complex phenotype. Here, we present CRISPR-Cas9 cytidine-base-editor (CBE) assisted evolution by continuously delivering a combinatorial sgRNA library to filamentous fungi.
View Article and Find Full Text PDFSelective Laser Sintering 3D Printing of Carvedilol Tablets: Enhancing Dissolution Through Amorphization.
Pharmaceutics
December 2024
Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
Background/objectives: Selective laser sintering (SLS) is one of the most promising 3D printing techniques for pharmaceutical applications as it offers numerous advantages, such as suitability to work with already approved pharmaceutical excipients, the elimination of solvents, and the ability to produce fast-dissolving, porous dosage forms with high drug loading. When the powder mixture is exposed to elevated temperatures during SLS printing, the active ingredients can be converted from the crystalline to the amorphous state, which can be used as a strategy to improve the dissolution rate and bioavailability of poorly soluble drugs. This study investigates the potential application of SLS 3D printing for the fabrication of tablets containing the poorly soluble drug carvedilol with the aim of improving the dissolution rate of the drug by forming an amorphous form through the printing process.
View Article and Find Full Text PDFMaximizing H Production from a Combination of Catalytic Partial Oxidation of CH and Water Gas Shift Reaction.
Molecules
January 2025
The Joint Graduate School of Energy and Environment, CHE Center for Energy Technology and Environment, King Mongkut's University of Technology Thonburi, 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok 10140, Thailand.
A single-bed and dual-bed catalyst system was studied to maximize H production from the combination of partial oxidation of CH and water gas shift reaction. In addition, the different types of catalysts, including Ni, Cu, Ni-Re, and Cu-Re supported on gadolinium-doped ceria (GDC) were investigated under different operating conditions of temperature (400-650 °C). Over Ni-based catalysts, methane can easily dissociate on a Ni surface to give hydrogen and carbon species.
View Article and Find Full Text PDFEquation for Calculation of Critical Current Density Using the Bean's Model with Self-Consistent Magnetic Units to Prevent Unit Conversion Errors.
Materials (Basel)
January 2025
Laboratory for Heteroepitaxial Growth of Functional Materials & Devices, Department of Chemical & Biological Engineering, State University of New York (SUNY) at Buffalo, Buffalo, NY 14260, USA.
This study analyzes the calculation of the critical current density by means of Bean's critical state model, using the equation formulated by Gyorgy et al. and other similar equations derived from it reported in the literature. While estimations of using Bean's model are widely performed, improper use of different equations with different magnetic units and pre-factors leads to confusion and to significant errors in the reported values of .
View Article and Find Full Text PDFSalvianolic acid B drives gluconeogenesis and peroxisomal redox remodeling in cardiac ischemia/reperfusion injury: A metabolism regulation by metabolite signal crosstalk.
Free Radic Biol Med
January 2025
Shanxi Key Laboratory of Innovative Drug for the Treatment of Serious Diseases Basing on the Chronic Inflammation, College of Traditional Chinese Medicine and Food Engineering, Shanxi University of Chinese Medicine, Taiyuan, Shanxi 030619, China; School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China; Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan 030001, China. Electronic address:
Cardiac metabolism relies on glycogen conversion by glycolysis. Glycolysis intersects fatty acid oxidation and often directs a signal crosstalk between redox metabolites. Myocardium with ischemia/reperfusion significantly diverts from normal metabolism.
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