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Muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis: protocol for a systematic review and meta-analysis.
F1000Res
January 2025
German Center for Mental Health (DZPG), partner site München/Augsburg, Munich, Germany.
Background: Muscarinic receptor agonism and positive allosteric modulation is a promising mechanism of action for treating psychosis, not present in most D2R-blocking antipsychotics. Xanomeline, an M1/M4-preferring agonist, has shown efficacy in late-stage clinical trials, with more compounds being investigated. Therefore, we aim to synthesize evidence on the preclinical efficacy of muscarinic receptor agonists and positive allosteric modulators in animal models of psychosis to provide unique insights and evidence-based information to guide drug development.
View Article and Find Full Text PDFRisk-stratified Care Improves Pain-related Knowledge and Reduces Psychological Distress for Low Back Pain: A Secondary Analysis of a Randomized Trial.
Clin Orthop Relat Res
January 2025
Department of Rehabilitation Medicine, Brooke Army Medical Center, JBSA Fort Sam Houston, TX, USA.
Background: A number of efforts have been made to tailor behavioral healthcare treatments to the variable needs of patients with low back pain (LBP). The most common approach involves the STarT Back Screening Tool (SBST) to triage the need for psychologically informed care, which explores concerns about pain and addresses unhelpful beliefs, attitudes, and behaviors. Such beliefs that pain always signifies injury or tissue damage and that exercise should be avoided have been implied as psychosocial mediators of chronic pain and can impede recovery.
View Article and Find Full Text PDFGemcitabine and ATR inhibitors synergize to kill PDAC cells by blocking DNA damage response.
Mol Syst Biol
January 2025
Chair of Proteomics and Bioanalytics, Technical University of Munich, Freising, Germany.
The DNA-damaging agent Gemcitabine (GEM) is a first-line treatment for pancreatic cancer, but chemoresistance is frequently observed. Several clinical trials investigate the efficacy of GEM in combination with targeted drugs, including kinase inhibitors, but the experimental evidence for such rationale is often unclear. Here, we phenotypically screened 13 human pancreatic adenocarcinoma (PDAC) cell lines against GEM in combination with 146 clinical inhibitors and observed strong synergy for the ATR kinase inhibitor Elimusertib in most cell lines.
View Article and Find Full Text PDFLong-term effect of non-invasive brain stimulation on hemispatial neglect, functional outcomes, and mortality after stroke: ELETRON trial extend.
Clin Neurol Neurosurg
January 2025
Department of Neurocience and Mental Health, Botucatu Medical School (UNESP), Botucatu, São Paulo, Brazil.
Introduction: Our primary clinical trial indicated that anodal stimulation of the right posterior parietal region associated with specific and perceptual task training was superior to placebo in reducing stroke-induced hemispatial neglect (HN) immediately after the treatment protocol. However, our primary study did not investigate whether this benefit was maintained in the long term after stroke. Therefore, this study aimed to evaluate the long-term effects of the protocol applied in the ELETRON trial on outcomes associated with HN, functionality, and mortality.
View Article and Find Full Text PDF"Just-in-time" but a bit delayed: Personalizing digital nudges for healthier online food choices.
Appetite
February 2025
Tilburg University, Department of Communication & Cognition, P.O. Box 90153, 5000 LE, Tilburg, the Netherlands. Electronic address:
As food choices are increasingly made in contexts such as online supermarkets, nudging has been extrapolated to the digital sphere. Digitalization poses unique opportunities to enhance the promotion of healthier food choices online: Digital nudges can be delivered "just-in-time" (JIT), in response to the initial selection of an unhealthy product. Furthermore, digital JIT nudges can be personalized to match user characteristics of behavioral relevance, such as one's food and cognitive processing preferences.
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