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Side effects following administration of open-placebos: A randomized controlled trial.
J Psychosom Res
February 2025
Health Psychology, Faculty of Medical and Health Sciences, University of Auckland, New Zealand. Electronic address:
Objective: To assess whether individuals reported more side effects and decreased mood after receiving an open-label placebo compared to a control group that received no treatment.
Methods: We randomized participants to receive an open placebo or no treatment. The primary outcome was reported side effects on the Side effect Attribution Scale (SEAS) at 15 min and at 24-h.
[Placebo effect in the treatment with antidepressants : Implications for the scientific evaluation and clinical use of pharmaceutical treatments of depression].
Nervenarzt
December 2024
Klinische Psychologie und Psychotherapie, Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau, Landau, Deutschland.
Background: Blinded placebo treatment arms in clinical trials often achieve up to 80% of the clinical improvements of the verum groups. Apparently, the majority of the effects found in the antidepressant groups in clinical trials are due to factors that are not specific to antidepressant treatment. This article reviews the factors that contribute to the high effectiveness of placebo interventions for antidepressants.
View Article and Find Full Text PDFReconsidering the ethics of provocation techniques for Psychogenic Non-Epileptic Attacks and proposed ethical guidelines for use.
Epilepsy Behav
December 2024
University Hospitals, Cleveland Medical Center, Department of Neurology, 11100 Euclid Ave., Cleveland, OH 44106; Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106.
Patients with psychogenic non-epileptic attacks (PNEA) are subject to considerable direct and indirect comorbid psycho-socio-economic impact from their condition. Fortunately, diagnosis and treatment of PNEA has shown to be both medically effective and cost-efficient, ultimately improving PNEA symptoms, mental health, quality of life, and healthcare resource utilization. Though provocation techniques for PNEA have proven highly effective in diagnosing and providing expedited treatment to these patients, they have recently begun to fall out of favor due to ethical concerns about their use.
View Article and Find Full Text PDFPlacebo and nocebo effects in gambling disorder pharmacological trials: a meta-analysis.
Acta Neuropsychiatr
November 2024
Department of Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, UK.
Background: Placebo and nocebo effects are widely reported across psychiatric conditions, yet have seldom been examined in the context of gambling disorder. Through meta-analysis, we examined placebo effects, their moderating factors, and nocebo effects, from available randomised, controlled pharmacological clinical trials in gambling disorder.
Methods: We searched, up to 19 February 2024, a broad range of databases, for double-blind randomised controlled trials (RCTs) of medications for gambling disorder.
Understanding Placebo and Nocebo Responses Based on a Randomized Sham-Controlled Study on Acupuncture in Integrative Cancer Care.
Integr Cancer Ther
November 2024
University of Gävle, Gävle, Sweden.
Since placebo and nocebo-responses during acupuncture therapy are rarely studied in clinical contexts, the objective was to investigate placebo and nocebo-responses in a clinical context through comparing positive and negative side-effects between genuine and sham acupuncture, and to identify factors modifying placebo and nocebo-responses. Patients reported positive side-effects (non-intended positive effects) or negative side-effects (non-intended negative effects) of genuine (penetrating; n = 109) or sham (telescopic non-penetrating; n = 106) acupuncture during 5 weeks of chemoradiation for cancer. The genuine and the sham acupuncture group reported rather similar frequencies of positive -values .
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