AI Article Synopsis
- The research examined IVF outcomes of women with high AMH levels in PCOS patients versus non-PCOS patients.
- A study with 238 women revealed that PCOS patients had higher median AMH levels and required less gonadotropin while producing more oocytes.
- PCOS patients were also more likely to experience hyperresponse to ovarian stimulation compared to their non-PCOS counterparts.
Article Abstract
Background: The purpose of this research was to investigate whether high AMH levels in PCOS patients resulted in different IVF outcomes compared to those in non-PCOS patients.
Methods: A retrospective cohort study was conducted involving 238 women undergoing IVF who had AMH levels > 4 ng/ml. Participants were divided into two groups: PCOS and non-PCOS.
Results: The median AMH level was significantly higher in the PCOS group (7.59 ± 4.61 ng/ml vs. 5.91 ± 2.22 ng/ml, p < 0.001). The PCOS group required less gonadotropin but yielded more oocytes after stimulation. Significantly more participants from the PCOS group (41.5% [n = 39]) developed a hyperresponse to ovarian stimulation compared to the non-PCOS group (26.4% [n = 38]) (OR = 1.978, 95% CI 1.138-3.488; p = 0.015).
Conclusion: There were significant differences in terms of total doses of gonadotropin and the number of oocytes retrieved in the PCOS and non-PCOS groups. Women with PCOS and high AMH levels have a higher risk of hyperresponse after ovarian stimulation than women without PCOS.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9107208 | PMC |
| http://dx.doi.org/10.1186/s12905-022-01756-4 | DOI Listing |
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