AI Article Synopsis
- High rates of carbapenem resistance in Brazilian Pseudomonas aeruginosa are linked to a specific clone (ST277) that produces a type of carbapenemase called SPM-1.
- Researchers used whole genome sequencing to analyze the genetic make-up of a plasmid containing the bla gene in these resistant isolates and found a new bla-plasmid.
- The study highlights the urgent need for public health measures to track the spread of this plasmid due to its connection with a high-risk bacterial clone.
Article Abstract
The high rates of carbapenem resistance among Brazilian Pseudomonas aeruginosa isolates are mainly associated with the clone ST277 producing the carbapenemase SPM-1. Here, the complete genetic composition of a IncP plasmid harboring bla in isolates of this endemic clone carrying chromosomal bla was described using whole genome sequencing. These results confirm the association of these two carbapenemases in ST277 and also describe the genetic composition of a novel bla-plasmid. Considering the fact that this association occurs in a high-risk clone, monitoring the dissemination of this plasmid should be a public health concern.
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| http://dx.doi.org/10.1016/j.meegid.2022.105302 | DOI Listing |
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