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| http://dx.doi.org/10.1111/all.15369 | DOI Listing |
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Article Synopsis
- Acupoint Catgut Embedding (ACE) is a modified acupuncture technique aimed at providing therapeutic effects for various diseases, but its local stimulation mechanisms are not fully understood.
- This study examines how ACE influences TRPV2 and TRPV4 ion channels at the Zusanli (ST36) acupoint in rats by embedding a PGLA suture and using inhibitors to measure changes in cellular responses.
- Findings reveal that ACE significantly enhances the expression of TRPV2 and TRPV4, intracellular calcium levels, and markers for certain immune cells, but these effects decrease over time, indicating a complex interaction between mechanical stimulation and calcium signaling pathways.
Redefining tryptase norms in the pediatric population reveals sex-based differences: Clinical implications.
Allergy
October 2024
CEREMAST, Imagine Institute, INSERM U1163, AP-HP, Necker-Children's Hospital, Paris Centre University, Paris, France.
mushroom anaphylaxis: A case report and review of the literature.
J Allergy Clin Immunol Glob
November 2024
AllergySA, Beulah Park, Adelaide, Australia.
Background: Anaphylaxis in response to edible mushrooms is uncommon, and sensitization may be independent of occupational exposure. Globally, is one the most cultivated mushroom species, comprising the button, portobello, and Swiss brown varietals.
Objective: Our aim was to describe a case of anaphylaxis in an older nonatopic patient following ingestion of and undertake a review of the literature.
Harmonization of Diagnostic Criteria in Mastocytosis for Use in Clinical Practice: WHO vs ICC vs AIM/ECNM.
J Allergy Clin Immunol Pract
December 2024
Division of Allergy and Clinical Immunology, University of Michigan, Ann Arbor, Mich.
Article Synopsis
- - Mastocytosis is a disorder characterized by an abnormal increase of mast cells in one or more organs, with varying symptoms and outcomes; it's classified into cutaneous, systemic, and MC sarcoma types by the WHO.
- - The disease often involves a specific mutation (D816V) in most systemic mastocytosis cases, affecting life expectancy significantly based on the type, with those having nonadvanced forms generally living near-normal lifespans, while advanced forms have limited life expectancies.
- - Recently, a group of experts proposed updated diagnostic criteria and classifications for mastocytosis, aiming to unify different classifications from previous organizations to improve research and clinical comparisons.
Cathepsin C in health and disease: from structural insights to therapeutic prospects.
J Transl Med
August 2024
Center of Excellence in Genomics and Precision Dentistry, Department of Physiology, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.
Article Synopsis
- * The review covers the structure, function, and genetic variants of CTSC, linking them to several syndromes like Papillon-Lefevre syndrome, Haim-Munk Syndrome, and aggressive periodontitis, which involve skin and dental issues.
- * CTSC's role in diseases like chronic obstructive pulmonary disease, COVID-19, and various cancers highlights its potential as a target for new therapies in autoimmune and inflammatory conditions.
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