Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. The current review investigated various therapeutic applications of different nano-phytopharmaceuticals in locomotor, dermal, reproductive, and urinary tract disorders to enhance bioavailability and efficacy of phytochemicals and herbal extracts in preclinical and in vitro studies. There is a lack of clinical and extensive preclinical studies. The research in this field is expanding but strong evidence on the efficacy of these nano-phytopharmaceuticals for human use is still limited. The long-term efficacy and safety of nano-phytopharmaceuticals must be ensured with priority before these materials emerge as common human therapeutics. Overall, this review provides up-to-date information on related contemporary research on nano-phytopharmaceuticals and nano-extracts in the fields of dermatological, urogenital, and locomotor disorders.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099949PMC
http://dx.doi.org/10.3390/plants11091265DOI Listing

Publication Analysis

Top Keywords

urogenital locomotor
8
locomotor disorders
8
phytochemicals nano-phytopharmaceuticals
4
nano-phytopharmaceuticals skin
4
skin urogenital
4
disorders there?
4
there? nanomedicines
4
nanomedicines emerged
4
emerged nanotechnology
4
nanotechnology introduced
4

Similar Publications

This study aims to reveal the effects and mechanisms of different fractions of Polygonati Rhizoma on the reproductive dysfunction in male mice with kidney essence deficiency due to excess of sexual intercourse. Fifty male ICR mice with good sexual function were selected and randomized into normal(NC), model(MC), n-butanol fraction of Polygonati Rhizoma(0.4 g·kg~(-1), HJCT), remaining fraction of Polygonati Rhizoma(0.

View Article and Find Full Text PDF

Disruption of local circadian clocks in aristolochic acid-induced nephropathy in mice.

Phytomedicine

December 2024

Institute of Molecular Rhythm and Metabolism, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Background: Aristolochic acid I (AAI), an emerging biogenic contaminant widely present in Aristolochic plants, has been implicated in the progression of tubulointerstitial disease, known as aristolochic acid nephropathy (AAN). The circadian clock, a vital regulator of organ homeostasis, is susceptible to external chemical cues, including toxins. However, the reciprocal interactions between AAI and the circadian clock remain unexplored.

View Article and Find Full Text PDF

Background: Aedes albopictus (Skuse 1894) mosquitoes can transmit deadly arboviruses and are globally invasive due to their ability to survive in both tropical and temperate climates. Although adults cannot survive harsh winters, females are capable of anticipating seasonal change and producing overwintering diapause (DP) eggs that remain in a state of arrested development over the winter and hatch when favorable conditions return in the spring. While low temperatures can facilitate DP entry under short photoperiods, temperature signals alone are not sufficient to induce DP.

View Article and Find Full Text PDF

Long-Term Administration of Nicotinamide Mononucleotide Mitigates High-Fat-Diet-Induced Physiological Decline in Aging Mice.

J Nutr

January 2025

Academy of Nutrition and Health, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, School of Public Health, Wuhan University of Science and Technology, Wuhan, China; Department of Pharmacy, Institute of Pharmaceutical Process, College of Medicine, Wuhan University of Science and Technology, Wuhan, China; Wuhan Asia General Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, China. Electronic address:

Article Synopsis
  • NAD levels decrease with age, and supplementing with nicotinamide mononucleotide (NMN), a precursor to NAD, could potentially improve health and longevity in mice on a high-fat diet.
  • Long-term NMN treatment resulted in increased NAD levels, reduced obesity, enhanced physical activity, and improved functions of skeletal muscle and kidneys, while also mitigating age-related inflammation.
  • The study suggests NMN may protect against diet-induced damage by affecting the autophagic pathway and regulating autophagy levels in different tissues.
View Article and Find Full Text PDF
Article Synopsis
  • * Various tests including the forced swim test, cystometry, and biochemical analyses were conducted to evaluate the impact of a 7-day TCS administration on bladder function and depressive behaviors.
  • * Results indicate that TCS improved bladder overactivity and reversed depressive signs, suggesting a potential link between the orexin system and both urinary bladder function and depression.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!