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Pediatric nasolacrimal duct intubation using deep sedation outside the operating room- comparison of three types of stents.
J AAPOS
December 2024
University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:
Background: Congenital nasolacrimal duct obstructions that persist after 9 months of age often require surgical intervention through probing and stenting of the tear duct. These procedures typically occur under general anesthesia in an operating room setting. We propose a novel approach using intravenous sedation outside the operating room.
View Article and Find Full Text PDFThe presence of CpGs in AAV gene therapy vectors induces a plasmacytoid dendritic cell-like population very early after administration.
Cell Immunol
May 2024
REGENXBIO Inc., 9804 Medical Center Drive, Rockville, MD 20850, USA.
AAV-mediated gene transfer is a promising platform still plagued by potential host-derived, antagonistic immune responses to therapeutic components. CpG-mediated TLR9 stimulation activates innate immune cells and leads to cognate T cell activation and suppression of transgene expression. Here, we demonstrate that CpG depletion increased expression of an antibody transgene product by 2-3-fold as early as 24 h post-vector administration in mice.
View Article and Find Full Text PDFCharacterization and biodistribution of under-employed gene therapy vector AAV7.
J Virol
November 2023
Research and Early Development, REGENXBIO Inc. , Rockville, Maryland, USA.
The use of adeno-associated viruses (AAVs) as gene delivery vectors has vast potential for the treatment of many severe human diseases. Over one hundred naturally existing AAV capsid variants have been described and classified into phylogenetic clades based on their sequences. AAV8, AAV9, AAVrh.
View Article and Find Full Text PDFDeveloping Functional Relationships between Soil Moisture Content and Corn Early-Season Physiology, Growth, and Development.
Plants (Basel)
June 2023
Department of Plant and Soil Sciences, Mississippi State University, Mississippi State, MS 39762, USA.
Drought is a severe threat to agriculture production that affects all growth stages of plants, including corn ( L.). Any factor affecting early seedling growth and development will significantly impact yield.
View Article and Find Full Text PDFAcute angle-closure in juvenile X-linked retinoschisis.
J AAPOS
June 2023
Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address:
Juvenile X-linked retinoschisis (JXR), the most common inherited retinal disorder in young males, presents with a wide range of phenotypic variations. Acute angle closure in children with JXR has been reported in the literature only once before. We present a case of acute-angle closure, temporally associated with pharmacologic dilation, in a 12-year-old boy with JXR.
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