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species are the main fungal agents causing infectious conditions in hospital patients. The development of new drugs with antifungal potential, increased efficacy, and reduced toxicity is essential to face the challenge of fungal resistance to standard treatments. The aim of this study is to evaluate the in vitro antifungal effects of two crude extracts of L., a rich alkaloid fraction and lycorine alkaloid, on the species. As such, we used a disk diffusion susceptibility test, determined the minimum inhibitory concentration (MIC), and characterized the components of the extracts using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (ESI FT-ICR MS). The extracts were found to have antifungal activity against various species. The chemical characterization of the extracts indicated the presence of alkaloids such as lycorine and crinine. The Amaryllidaceae family has a promising antifungal potential. Furthermore, it was found that the alkaloid lycorine directly contributes to the effects that were observed for the extracts and fraction of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9100883 | PMC |
| http://dx.doi.org/10.3390/molecules27092976 | DOI Listing |
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- - It found that bulbs contain specific alkaloids like crinane and galanthamine, while roots have a significantly higher concentration of lycorine and galanthamine, indicating that roots produce more alkaloids overall.
- - The research indicates that the total alkaloid extracts from both bulbs and roots show a dose-dependent cytotoxic effect on human lung and gastric cancer cells, suggesting their potential as antiproliferative agents.
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