Isatropolones/isarubrolones are actinomycete secondary metabolites featuring a tropolone-ring in their structures. From the isatropolone/isarubrolone producer sp. CPCC 204095, 7,12-dihydroisatropolone C (HITC) is discovered and identified as a mixture of two interchangeable diastereomers differing in the C-6 configuration. As a major metabolite in the mycelial growth period of sp. CPCC 204095, HITC can be oxidized spontaneously to isatropolone C (ITC), suggesting HITC is the physiological precursor of ITC. Characterization of HITC makes us propose dihydrotropolone-ring construction in the biosynthesis of isatropolones.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9099902 | PMC |
| http://dx.doi.org/10.3390/molecules27092882 | DOI Listing |
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