AI Article Synopsis
- Hayata is a native Taiwanese plant known for its medicinal uses, particularly in pain relief and eliminating toxins.
- The study isolated nineteen compounds from Hayata twigs and tested their effects on melanoma in a mouse model, identifying several types of compounds such as triterpenoids and flavonoids.
- While some compounds exhibited moderate cytotoxic effects, the overall anti-melanoma activity was tied to the combined effect of all components, indicating potential synergistic properties that require further exploration.
Article Abstract
Hayata () is an endemic plant in Taiwan. According to the Chinese Materia Medica Grand Dictionary, the species is mainly used to relieve pain, and eliminate pus and toxicity. In this study, nineteen compounds were isolated from the ethyl acetate layer of the ethanolic extract of Hayata twigs using bioassay-guided fractionation, and their anti-melanoma effects were investigated through a B16-F10 mouse melanoma cell model. The structures of the purified compounds were identified by 2D-NMR, MS, and IR, including 1 triterpenoid, 9 diterpenoids, 2 lignans, 4 phenolics, 1 phenylpropanoid, 1 flavonoid, and 1 steroid. Among them, compound was found to be a new diterpene. Some of the compounds (, , , , ) showed moderate cytotoxicity effects. On the other hand, the anti-melanoma effect was no better than that from the original ethyl acetate layer. We presumed it resulted from the synergistic effect, although further experimentation needs to be performed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9103300 | PMC |
| http://dx.doi.org/10.3390/molecules27092731 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cytotoxicity Effect of Constituents of Hayata Twigs on B16-F10 Melanoma Cells.
Molecules
April 2022
Graduate Institute of Pharmacognosy, Taipei Medical University, 250 Wu Xin Street, Taipei 11031, Taiwan.
Article Synopsis
- Hayata is a native Taiwanese plant known for its medicinal uses, particularly in pain relief and eliminating toxins.
- The study isolated nineteen compounds from Hayata twigs and tested their effects on melanoma in a mouse model, identifying several types of compounds such as triterpenoids and flavonoids.
- While some compounds exhibited moderate cytotoxic effects, the overall anti-melanoma activity was tied to the combined effect of all components, indicating potential synergistic properties that require further exploration.
Naturally Occurring Cytotoxic [3'→8″]-Biflavonoids from Podocarpus nakaii.
J Tradit Complement Med
July 2012
National Research Institute of Chinese Medicine, Taipei 112, Taiwan ; Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
Bioassay-guided fractionation of the EtOH extract of the dried twigs of Podocarpus nakaii Hayata (Podocarpaceae), endemic plant in Taiwan has resulted in isolation of four [3'→8″]-biflavonoid derivatives, amenotoflavone (AF), podocarpusflavone-A (PF), II-4″,I-7-dimethoxyamentoflavone (DAF), and heveaflavone (HF). Their structures were determined by physical and extensive spectroscopic analyses such as (1)H, (13)C, (1)H-(1)H COSY, HMQC, and HMBC, as well as comparison with literature values. Compounds PF and DAF showed significant inhibitions against DLD, KB, MCF-7, HEp-2 tumor cell lines (ED50 ca.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!