A pronounced cholagogic effect of kaleflon was found in the experiment on albino rats. The course administration of kaleflon in a dose of 0.05 g/kg exerts a marked pharmacotherapeutic action on the course of experimental hepatitis.
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Is Overlain Display a Right Choice for AR Navigation? A Qualitative Study of Head-Mounted Augmented Reality Surgical Navigation on Accuracy for Large-Scale Clinical Deployment.
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Background: During the course of the past two decades, head-mounted augmented reality surgical navigation (HMARSN) systems have been increasingly employed in a variety of surgical specialties as a result of both advancements in augmented reality-related technologies and surgeons' desires to overcome some drawbacks inherent to conventional surgical navigation systems. In the present time, most experimental HMARSN systems adopt overlain display (OD) that overlay virtual models and planned routes of surgical tools on corresponding physical tissues, organs, lesions, and so forth, in a surgical field so as to provide surgeons with an intuitive and direct view to gain better hand-eye coordination as well as avoid attention shift and loss of sight (LOS), among other benefits during procedures. Yet, its system accuracy, which is the most crucial performance indicator of any surgical navigation system, is difficult to ascertain because it is highly subjective and user-dependent.
View Article and Find Full Text PDFSignatures of H3K4me3 modification predict cancer immunotherapy response and identify a new immune checkpoint-SLAMF9.
Respir Res
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Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
H3 lysine 4 trimethylation (H3K4me3) modification and related regulators extensively regulate various crucial transcriptional courses in health and disease. However, the regulatory relationship between H3K4me3 modification and anti-tumor immunity has not been fully elucidated. We identified 72 independent prognostic genes of lung adenocarcinoma (LUAD) whose transcriptional expression were closely correlated with known 27 H3K4me3 regulators.
View Article and Find Full Text PDFAnakinra improves retention rate of targeted treatments in Erdheim-Chester disease.
Rheumatology (Oxford)
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Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
Objective: Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis that exhibits a wide spectrum of clinical manifestations. The recent identification of activating mutations in the MAPK-ERK pathway in patients with ECD has led to the introduction of targeted therapies. The most commonly used targeted therapies are BRAF- and MEK-inhibitors, which are highly effective but also carry significant toxicity.
View Article and Find Full Text PDFAn integrative review of the effects of high-intensity interval training on the autonomic nervous system.
Sports Med Health Sci
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High-Intensity Interval Training (HIIT) has gained prominence as a time-efficient and effective exercise modality to improve cardiovascular (CV) fitness, metabolic health, and physical performance. Therefore, our aim was to synthesize current clinical research on the effects of HIIT on the Autonomic Nervous System. We conducted the search for studies in the Directory of Open Access Journals, Embase, Virtual Health Library, Pubmed, and Scielo databases, in January of 2024.
View Article and Find Full Text PDFInternal mammary node irradiation in 4541 node-positive breast cancer patients treated with newer systemic therapies and 3D-based radiotherapy (DBCG IMN2): a prospective, nationwide, population-based cohort study.
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Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
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