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C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.
Published: May 2022
AI Article Synopsis
Ovarian cancer happens in a part of the body called the peritoneal cavity, which has a lot of fat tissue.
Studies show that fat cells, or adipocytes, help ovarian cancer grow and spread by affecting how the cancer cells behave.
This review talks about important research on fat cells and ovarian cancer, and it suggests more questions to explore in future studies.
Article Abstract
The tumor microenvironment of ovarian cancer is the peritoneal cavity wherein adipose tissue is a major component. The role of the adipose tissue in support of ovarian cancer progression has been elucidated in several studies from the past decades. The adipocytes, in particular, are a major source of factors, which regulate all facets of ovarian cancer progression such as acquisition of chemoresistance, enhanced metastatic potential, and metabolic reprogramming. In this review, we summarize the relevant studies, which highlight the role of adipocytes in ovarian cancer progression and offer insights into unanswered questions and possible future directions of research.
