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Exploring the relationship between genetic diversity and antimalarial drugs resistance markers in a malaria-endemic region of Burkina Faso.
Pan Afr Med J
November 2024
Université Joseph KI-ZERBO (UJKZ), Ouagadougou, Burkina Faso.
Introduction: the diversity of Plasmodium falciparum genotypes affects the dynamics of malaria transmission and is thought to be one of the factors hampering malaria control efforts. This study aimed to investigate the relationship between Plasmodium falciparum genetic diversity and chloroquine and sulfadoxine-pyrimethamine resistance markers in malaria endemic areas of Burkina Faso.
Methods: in a cross-sectional study, populations residing in Nouna health district were randomly recruited.
Characteristics of imported and domestic malaria cases in Gyeonggi Province, Korea.
Epidemiol Health
December 2024
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
Objectives: This study explored 11 years of malaria data from mandatory reporting in Gyeonggi Province, Korea, to provide information for prevention strategies by linkage to nationwide health claims data.
Methods: Reported malaria cases in Gyeonggi Province from 2011 to 2021 were linked to medical usage data from the National Health Insurance Database. Data about hospitalization, antibiotic prescription and duration, malarial species, and sociodemographic information of the cases were included.
Optimization of loop mediated isothermal amplification assay (LAMP) for detection of chloroquine resistance in P. vivax malaria.
Sci Rep
October 2024
Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Chloroquine is still used as a first-line treatment for uncomplicated Plasmodium vivax malaria in India and resistance to this therapy can act as a major hurdle for malaria elimination. It is difficult to monitor drug-efficacy and drug resistance through in vivo and in vitro studies in case of Plasmodium vivax so analysis of molecular markers serves as an important tool to track resistance. Molecular methods that are currently in use for detecting single nucleotide polymorphisms in resistant genes including Polymerase chain reaction (PCR), Realtime-Polymerase chain reaction require highly sophisticated labs and are time consuming.
View Article and Find Full Text PDFArtificial intelligence for detection of retinal toxicity in chloroquine and hydroxychloroquine therapy using multifocal electroretinogram waveforms.
Sci Rep
October 2024
Department of Ophthalmology, University Hospital Erlangen, Schwabachanlage 6, 91054, Erlangen, Germany.
Article Synopsis
- * This study investigates the effectiveness of AI algorithms in detecting retinal damage in patients using these medications, comparing traditional analysis methods with advanced AI approaches.
- * Results indicate that AI models using complete mfERG data are better at identifying disease-related changes than linear models, though challenges like an unbalanced dataset could affect their application.
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