AI Article Synopsis
- Statins, like pravastatin (PV), have a debated role in protecting against hearing loss caused by aminoglycoside drugs, specifically kanamycin (KM).
- In the study, adult rats were treated with KM, and some received PV, allowing researchers to measure changes in hearing using auditory brainstem response (ABR) thresholds.
- Results showed that while KM increased ABR thresholds (indicating hearing loss), the combination of PV and KM resulted in improved thresholds and better preservation of cochlear cells, suggesting PV's protective role against KM-induced hearing loss through regulating cellular processes like autophagy and apoptosis.
Article Abstract
The effect of statins on aminoglycoside-induced ototoxicity is controversial. This study aimed to explore the role of pravastatin (PV) in kanamycin-induced hearing loss in rats. Adult rats were intraperitoneally treated with 20 mg/kg/day of kanamycin (KM) for 10 days. In the PV- and PV + KM-treated rats, 25 mg/kg/day of PV was intraperitoneally administered for 5 days. The auditory brainstem response (ABR) thresholds were measured before and after drug treatment using a smartEP system at 4, 8, 16, and 32 kHz. Cochlear changes in poly ADP-ribose (PAR) polymerase (PARP), PAR, and caspase 3 were estimated using Western blotting. PV administration did not increase the ABR thresholds. The KM-treated rats showed elevated ABR thresholds at 4, 8, 16, and 32 kHz. The PV + KM-treated rats demonstrated lower ABR thresholds than the KM-treated rats at 4, 8, and 16 kHz. The cochlear outer hair cells and spiral ganglion cells were relatively preserved in the PV + KM-treated rats when compared with that in the KM-treated rats. The cochlear expression levels of PARP, PAR, and caspase 3 were higher in the KM-treated rats. The PV + KM-treated rats showed lower levels of PARP, PAR, and caspase 3 than the KM-treated rats. PV protected cochleae from KM-induced hearing loss in rats. The regulation of autophagy and apoptosis mediated the otoprotective effects of PV.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9105065 | PMC |
| http://dx.doi.org/10.3390/ijms23094524 | DOI Listing |
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Article Synopsis
- Statins, like pravastatin (PV), have a debated role in protecting against hearing loss caused by aminoglycoside drugs, specifically kanamycin (KM).
- In the study, adult rats were treated with KM, and some received PV, allowing researchers to measure changes in hearing using auditory brainstem response (ABR) thresholds.
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