AI Article Synopsis
- Hyperkalemia, or high potassium levels, is linked to decreased kidney function in non-dialysis chronic kidney disease patients, but its effects on residual kidney function in hemodialysis patients remain unclear.
- A study analyzed 6,655 hemodialysis patients from 2007 to 2011, categorizing their serum potassium levels and assessing changes in renal urea clearance over a year.
- Results revealed that higher potassium levels significantly contributed to a decline in kidney function, with a notable drop for those with potassium levels above 5.0 mEq/L, suggesting that managing hyperkalemia may be critical for patients with advanced chronic kidney disease.
Article Abstract
Background: Hyperkalemia is associated with kidney function decline in patients with non-dialysis dependent chronic kidney disease, but this relationship is unclear for residual kidney function (RKF) among hemodialysis (HD) patients.
Methods: We conducted a retrospective cohort study of 6655 patients, who started HD January 2007 and December 2011 and who had data on renal urea clearance (KRU). Serum potassium levels were stratified into four groups (i.e. ≤4.0, >4.0 to ≤4.5, >4.5 to ≤5.0 and >5.0 mEq/L) and 1-year KRU slope for each group was estimated by a linear mixed-effects model.
Results: Higher serum potassium was associated with a greater decline in KRU, and the greatest decrease in KRU (-0.20, 95% confidence interval -0.50 to -0.06) was observed for baseline potassium >5.0 mEq/L in the fully adjusted model. Mediation analysis showed that KRU slope mediated 1.78% of the association between serum potassium and mortality.
Conclusions: Hyperkalemia is associated with a decline in RKF amongst incident HD patients. These findings may have important clinical implications in the management of hyperkalemia in advanced CKD if confirmed in additional clinical trials.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9585465 | PMC |
| http://dx.doi.org/10.1093/ndt/gfac181 | DOI Listing |
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