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Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal. | LitMetric
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Evaluation of subclasses for T4-classified squamous cell carcinoma of the external auditory canal.

Cindy H Nabuurs Wietske Kievit C René Leemans Conrad F G M Smit Michiel W M van den Brekel Robert J Pauw Bernard F A M van der Laan Jeroen C Jansen Martin Lacko Weibel W Braunius Chunfu Dai Xunbei Shi Giovanni Danesi Jan Bouček Robert P Takes Henricus P M Kunst

Head Neck

Department of Otorhinolaryngology and Head and Neck Surgery - Academic Alliance Skull Base Pathology Radboudumc & MUMC+, Radboud University Medical Center, Nijmegen, the Netherlands.

Published: August 2022

AI Article Synopsis

  • - The study investigates the clinical importance of subclassifying T4-classified squamous cell carcinoma (SCC) of the external auditory canal (EAC) to improve treatment strategies and survival outcomes.
  • - Researchers analyzed data from 130 patients across 12 hospitals, focusing on different T4-subclasses proposed by Lavieille and Zanoletti, and found variations in treatment strategies and disease-free survival.
  • - Results suggest that Lavieille’s subclassification may enhance clinical practices for treating T4 EAC SCC, indicating its potential value in patient care.

Article Abstract

Background: T4-classified squamous cell carcinoma (SCC) of external auditory canal (EAC) can potentially involve different anatomical structures, which could translate into different treatment strategies and survival outcomes within one classification. Our aim is to evaluate the clinical added value of T4-subclasses proposed by Lavieille and by Zanoletti.

Methods: Retrospective data, including patients with primary operated cT4-classified EAC SCC, was obtained from 12 international hospitals. We subclassified according to the T4-subclasses. The treatment strategies, disease-free survival (DFS) and overall survival per subclass were calculated.

Results: A total of 130 T4-classified EAC SCC were included. We found commonly used treatment strategies per subclass according to Lavieille and the DFS seems also to differ per subclass. Subclass according to Zanoletti showed comparable treatment strategies and survival outcomes per subclass.

Conclusion: Our study suggests that the subclass according Lavieille might have added value in clinical practice to improve care of T4-classified EAC SCC.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9541903PMC
http://dx.doi.org/10.1002/hed.27082DOI Listing

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