Acyl-CoA-binding proteins (ACBPs) constitute a well-conserved family of proteins in eukaryotes that are important in stress responses and development. Past studies have shown that ACBPs are involved in maintaining, transporting and protecting acyl-CoA esters during lipid biosynthesis in plants, mammals, and yeast. ACBPs show differential expression and various binding affinities for acyl-CoA esters. Hence, ACBPs can play a crucial part in maintaining lipid homeostasis. This review summarizes the functions of ACBPs during the stages of reproduction in plants and other organisms. A comprehensive understanding on the roles of ACBPs during plant reproduction may lead to opportunities in crop improvement in agriculture.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jxb/erab499 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Extracellular acyl-CoA-binding protein as an independent biomarker of COVID-19 disease severity.
Front Immunol
January 2025
Inflammation and Immunity in Global Health Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Background: Factors leading to severe COVID-19 remain partially known. New biomarkers predicting COVID-19 severity that are also causally involved in disease pathogenesis could improve patient management and contribute to the development of innovative therapies. Autophagy, a cytosolic structure degradation pathway is involved in the maintenance of cellular homeostasis, degradation of intracellular pathogens and generation of energy for immune responses.
View Article and Find Full Text PDFIdentification and characterization of interacting proteins of transcription factor DpWRI1-like related to lipid biosynthesis from microalga .
Heliyon
January 2025
Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University), Ministry of Education, Guangxi Key Laboratory of Landscape Resources Conservation and Sustainable Utilization in Lijiang River Basin (Guangxi Normal University), University Engineering Research Center of Bioinformation and Genetic Improvement of Specialty Crops, Guangxi, Guilin, Guangxi, 541006, China.
Our previous study found that WRINKLED1-like (DpWRI1-like) was a key regulatory factor of lipid biosynthesis in . gene and target genes of DpWRI1-like have been obtained in our previous study, but the interacting proteins of DpWRI1-like are unclear now, which has limited a deep understanding of the function of DpWRI1-like. Yeast two-hybrid was widely used to identify protein-protein interaction.
View Article and Find Full Text PDFThe acyl-CoA-binding protein VdAcb1 is essential for carbon starvation response and contributes to virulence in .
aBIOTECH
December 2024
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193 China.
Unlabelled: In the face of carbon, nitrogen, and phosphorus starvation, microorganisms have evolved adaptive mechanisms to maintain growth. In a previous study, we identified a protein predicted to contain acyl-CoA-binding domains in the plant pathogenic fungus . The predicted protein, designated VdAcb1, possesses an atypical signal peptide.
View Article and Find Full Text PDFMembrane fluidity control by the Magnaporthe oryzae acyl-CoA binding protein sets the thermal range for host rice cell colonization.
PLoS Pathog
November 2024
Department of Plant Pathology, University of Nebraska-Lincoln, Lincoln, Nebraska, United States of America.
Article Synopsis
- The blast fungus Magnaporthe oryzae grows in rice cells through invasive hyphae (IH) and forms a biotrophic interfacial complex, essential for host-pathogen interactions.
- Disruption of the ACB1 gene, which is vital for fatty acid transport, affects the fungus’s ability to grow and cause disease at lower temperatures (22°C and 26°C) but not at elevated temperatures (29°C).
- Impaired membrane fluidity due to ACB1 loss at optimal and suboptimal temperatures is responsible for reduced pathogenicity, suggesting that understanding these thermal adaptations is crucial in the context of climate change impacts on plant diseases.
ACBP/DBI neutralization for the experimental treatment of fatty liver disease.
Cell Death Differ
November 2024
Centre de Recherche des Cordeliers, Inserm U1138, Université de Paris, Sorbonne Université, Equipe labellisée par la Ligue contre le cancer, Institut Universitaire de France, Paris, France.
Article Synopsis
- ACBP/DBI is a protein linked to metabolic-associated steatohepatitis and liver fibrosis, showing higher levels in affected patients, correlating strongly with NAFLD and FIB4 scores, regardless of age or body mass index.
- A study used a monoclonal antibody to neutralize ACBP/DBI in various mouse models of liver disease, resulting in reduced signs of liver damage and halting disease progression.
- The results suggest ACBP/DBI plays a causal role in liver conditions and could be a potential therapeutic target for treating liver diseases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!