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| http://dx.doi.org/10.1530/REP-22-0148 | DOI Listing |
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Systematic identification of Y-chromosome gene functions in mouse spermatogenesis.
Science
January 2025
Sex Chromosome Biology Laboratory, The Francis Crick Institute, London, UK.
The mammalian Y chromosome is essential for male fertility, but which Y genes regulate spermatogenesis is unresolved. We addressed this by generating 13 Y-deletant mouse models. In , , and deletants, spermatogenesis was impaired.
View Article and Find Full Text PDFoligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice.
Front Neurosci
January 2025
Beijing Key Laboratory of Bioactive Substances and Functional Food, Beijing Union University, Beijing, China.
Background: In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.
Methods: Chronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.
A new approach for hemodynamics of varicoceles: blood flow patterns based on contrast-enhanced ultrasound.
Basic Clin Androl
January 2025
Department of Ultrasound, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China.
Background: Hemodynamic alterations in the spermatic vein are implicated in infertility among patients with varicocele (VC). Contrast-enhanced ultrasound (CEUS), a powerful tool for hemodynamic analysis, remains unexplored for VC. This study aimed to demonstrate the feasibility of using CEUS to evaluate spermatic vein hemodynamics in patients with VC and establish a clear correlation between specific hemodynamic patterns and impaired semen parameters.
View Article and Find Full Text PDFVitamin D protects spermatogonia and Sertoli cells from heat stress damage by inhibiting NLRP3.
Front Pediatr
January 2025
Pathology Department, Anhui Provincial Children's Hospital, Hefei, Anhui, China.
Introduction: Cryptorchidism can damage cells in the cryptorchid testes due to elevated local temperatures, potentially impacting the fertility of the child in adulthood. Research indicates that vitamin D enhances sperm quality in adult males. This study aimed to explore whether vitamin D inhibits NLRP3 activation, thus helping to mitigate heat stress damage to testicular spermatogenic and Sertoli cells.
View Article and Find Full Text PDFAssociation between sperm DNA fragmentation index and recurrent pregnancy loss: results from 1485 participants undergoing fertility evaluation.
Front Endocrinol (Lausanne)
January 2025
Department of Reproductive Medicine, Nanyang Central Hospital, Nanyang, China.
Objective: Several male factors have been reported to play a role in recurrent pregnancy loss (RPL). The aim of this study is to explore the relationship between semen parameters, sperm DNA fragmentation index (DFI) and RPL.
Method: A total of 1485 participants were recruited from a university hospital between April 2020 and August 2022.
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