AI Article Synopsis
- - Copper-catalyzed cross-coupling reactions are used to combine vinyl epoxide with arylboronates to create aryl-substituted homoallylic alcohols.
- - This method shows different selectivity compared to past reactions using aryl nucleophiles for vinyl epoxide ring-opening.
- - The process occurs under mild conditions, resulting in high selectivity and good to excellent yields of the desired products.
Article Abstract
Copper-catalyzed cross-coupling reactions of vinyl epoxide with arylboronates to obtain aryl-substituted homoallylic alcohols are described. The reaction selectivity was different to that of previously reported vinyl epoxide ring-opening reactions using aryl nucleophiles. The reaction proceeded under mild conditions, affording aryl-substituted homoallylic alcohols with high selectivity and in good to excellent yields. The reaction provides convenient access to aryl-substituted homoallylic alcohols from vinyl epoxide.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9092012 | PMC |
| http://dx.doi.org/10.1039/c8ra09048c | DOI Listing |
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