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ALTERNATIVE BIOLOGICAL MODELS FOR EVALUATION OF THE TOXIC, GENOTOXIC AND MUTAGENIC POTENTIAL OF Ectatomma brunneum Smith VENOM.
Toxicon
January 2025
Faculty of Biological and Environmental Sciences, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil; Faculty of Exact Sciences and Technology, Federal University of Grande Dourados (UFGD), Dourados-Itahum Highway, Km 12 - Unit II, University City, 79804-970, Dourados, MS, Brazil.
The venom of Ectatomma brunneum is considered promising for drugs development. Therefore, it is important to evaluate its toxic potential and genetic instability using biological assays. To this end, toxicity assays were performed with Artemia salina, cytotoxicity and genotoxicity with Allium cepa and mutagenicity with Ames.
View Article and Find Full Text PDF-Lyophilized Fruit Extract Attenuated Acute Redox-Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephrotoxicity.
Pharmaceuticals (Basel)
January 2025
Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, 11 Armeiska Str., 6000 Stara Zagora, Bulgaria.
Gentamicin (GM) administration is associated with decreased metabolism, increased oxidative stress, and induction of nephrotoxicity. L., containing flavonoids, anthocyanins, and phytosterols, possesses antioxidant and anti-inflammatory potential.
View Article and Find Full Text PDFEffects of the Interactions Between Food Additive Titanium Dioxide and Matrices on Genotoxicity.
Int J Mol Sci
January 2025
Department of Food Science & Technology, Seoul Women's University, Seoul 01797, Republic of Korea.
Titanium dioxide (TiO), a white color food additive, is widely used in bakery products, candies, chewing gums, soups, and creamers. Concerns about its potential genotoxicity have recently emerged, particularly following the European Union's ban on its usage as a food additive due to its genotoxicity potential. Conflicting in vitro and in vivo results regarding its genotoxicity highlight the need for further in-depth investigation.
View Article and Find Full Text PDFEnhancing Industrial Hemp () Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications.
Int J Mol Sci
January 2025
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro, 53100 Siena, Italy.
The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports sustainable development goals by reducing reliance on synthetic chemicals in healthcare. biomass, in particular, has emerged as a valuable resource within this context. This study focuses on the hydroethanolic extract of leaves (CSE), which exhibited significant levels of phenolic compounds contributing to robust antioxidant activity.
View Article and Find Full Text PDFEvaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels.
Sci Rep
January 2025
Department of Hematology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003, China.
It has been documented that D-dimer levels have potential utility as a measure of tumor activity in diffuse large B-cell lymphoma (DLBCL), however whether it can be used as a predictive marker of treatment outcome has not been established. This study means to retrospectively evaluate the role of D-dimer in prediction of treatment efficacy in patients with DLBCL. 151 patients with newly diagnosed DLBCL were enrolled.
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